Judith Wardwell-Swanson

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The activities of metabotropic glutamate receptor (mGluR) standards were evaluated in the [35S]GTPgammaS binding assay and in the forskolin (FSK)-enhanced cyclic AMP assay using Chinese hamster ovary (CHO) cells or homogenates which expressed the human mGluR (hmGluR) subtypes 2 and 4. Though distinct rank orders of activities were determined for the(More)
Two voltage-gated potassium channels, hKv1.1 and hKv2.1, were stably expressed in Chinese hamster ovary cells. The effects of neurosteroids, pregnenolone sulfate (PS), 5alpha-pregnan-3alpha-ol-20-one sulfate (5alpha3alphaP), and 5beta-pregnan-3alpha-ol-20-one sulfate (5beta3alphaP), on hKv1.1 and hKv2.1 were studied using the patch-clamp method. PS,(More)
BACKGROUND P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lacking. Here we use cell-based studies and three murine models of atherogenesis to evaluate the impact of P2Y(6)(More)
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