Judith Randall

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Serial assessments of cognition, mood, and disability were carried out at nine month intervals over a 54 month period on a cohort of 87 patients with Parkinson's disease (PD) and a matched cohort of 50 control subjects. Dementia was diagnosed from data by rigorously applying DSM-III-R criteria. Initially, 6% (5/87) PD patients were demented, compared with(More)
It has recently been reported that male mice exhibit pronounced analgesia in response to attack from aggressive conspecifics. Although several studies indicate that this reaction can be blocked by opiate antagonist pretreatment, unequivocal evidence of opioid involvement is very much more limited. In the present study, the phenomenon of conflict analgesia(More)
Recent studies have indicated that defeat experience induces acute non-opioid analgesia in intruder mice. To investigate the potential involvement of benzodiazepine receptors in this biologically-relevant form of environmentally-induced antinociception, we initially assessed the effects of some benzodiazepine ligands on basal nociception (tail-flick assay).(More)
Exposure to repeated attack induces a long-lasting analgesia in male mice. Although this reaction has been linked to the special biological significance of defeat, earlier research has confounded defeat and exposure to further attack. In the present studies, DBA/2 intruder mice were individually placed into the home cages of aggressive conspecifics and(More)
Behavioural and pharmacological evidence indicates that non-opioid analgesia in defeated male mice is initiated by anxiety and that serotongergic (5-HT) substrates are implicated. In the present study, the effects of the novel putative 5-HT3 anxiolytic, GR38032F, on this form of adaptive inhibition of pain have been examined. The results showed that defeat(More)
Recent studies have shown that intruder mice display qualitatively different forms of analgesia in response to social encounters with resident conspecifics. An acute (non-opioid) reaction is evident when display of defeat is used as test criterion whereas a much longer-lasting (opioid) response is observed when this criterion is exceeded. Neither reaction(More)
Although it has recently been reported that defeated male mice evidence an acute non-opioid analgesia, little is currently known about the specific features of the defeat experience with which the analgesic reaction is associated. The present experiments not only confirm that defeat experience reliably induces acute antinociception in intruder mice, but(More)
Social conflict in mice is associated with at least two forms of analgesia. A long-lasting opioid reaction is evident in intruder mice exposed to prolonged attack, whilst an acute non-opioid analgesia is seen in response to either defeat experience per se or the territorial scent-marking of an aggressive conspecific. Recent work from this laboratory has(More)
In male mice, the biologically significant experience of social defeat is associated with an acute non-opioid form of analgesia. Recent studies have shown that this reaction is sensitive to certain benzodiazepine receptor ligands but is unaffected by others. The present experiments were designed to assess the possibility that activity at “non-neuronal”(More)
Two forms of analgesia (opioid and non-opioid) are associated with social conflict in mice. The non-opioid form is seen in response to the scent of an aggressive conspecific or defeat experience, whilst the opioid form occurs in response to extended conspecific attack. Recently, it has been reported that the non-opioid reaction is dose-dependently blocked(More)