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Brain tumors pose a particular challenge to molecular oncology. Many different tumor entities develop in the nervous system and some of them appear to follow distinct pathogenic routes. Molecular genetic alterations have increasingly been reported in nervous system neoplasms. However, a considerable number of affected genes remain to be identified. We(More)
The effects of injections of the neuropeptide substance P or the GABA agonist muscimol on performance of a step-down inhibitory avoidance task were examined. Immediately after the training trial, rats with chronically implanted cannulas were injected with 100 or 10 ng of substance P or 500 or 50 ng of muscimol into the region of the nucleus basalis(More)
Performance on visual tracking tasks was measured in groups of Alzheimer-type dementia, pseudodementia of depression, and elderly normal controls. Smooth pursuit tracking errors were identified by counting the number of catch-up saccades required to compensate for failure of the smooth pursuit system. The group with Alzheimer-type dementia had significantly(More)
WHO grades II and III astrocytomas frequently exhibit loss of genetic material on chromosomes 9p, 11p, 17p, 19q, and 22q, indicating that these chromosomal regions harbor tumor suppressor genes involved in the pathogenesis of astrocytic neoplasms. The present study was conducted to examine whether these genetic regions are involved in the process of(More)
There is evidence that a putative glioma tumor suppressor locus resides on the long arm of chromosome 19. We present data on 161 gliomas from 156 patients, which were studied by microsatellite analysis for loss of heterozygosity (LOH) on chromosome 19. Eight loci on the long arm and 2 loci on the short arm of chromosome 19 were examined. LOH on 19q was(More)
Concentrations of dopamine, serotonin, and some of their metabolites were analyzed by means of high-performance liquid chromatography in brain samples obtained from rats operantly conditioned to use one paw for water-reinforced lever pressing. In the first experiment, the side of paw usage was determined by physical constraint (forced-handedness condition),(More)
The effect of age and gender on eye tracking performance was studied in normal healthy subjects. Two measures of tracking performance, phase corrected cross-correlation coefficients and number of catch-up saccades were determined. The cross-correlation measures revealed a differential effect with the elderly men demonstrating significantly better tracking(More)
Individuals with an inherited predisposition to cancer development are at an increased risk of developing multiple tumours. Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most common hereditary cancer syndromes and is estimated to account for approximately 2% of colorectal cancers. However, HNPCC individuals are at an increased risk of(More)
BACKGROUND The hypotheses that Swedish patients with four or more primary tumours [including at least one cutaneous malignant melanoma (CMM)] harbour an increased number of CDKN2A (formerly p16) germline mutations, and that this group of patients show a predisposition to other tumours, e.g. nonmelanoma skin cancer (NMSC), were studied descriptively. So far(More)
High mortality rate in rats with large medial preoptic lesions discourage their use in studies of brain function. However, virtually all such animals (six out of seven) survived indefinitely if kept at an ambient temperature of 15 degrees C for 2 hours before and 10 to 12 hours after the lesions were made. Although these rats appeared otherwise healthy,(More)