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BACKGROUND Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene encoding the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ). OBJECTIVE We sought to review the clinical, immunologic, histopathologic, and radiologic features of APDS in(More)
Respiratory disease is a significant cause of morbidity and mortality amongst patients with primary immunodeficiency disorders. Computed tomography (CT) plays an important role in the multidisciplinary approach to these conditions, in detecting, characterizing, and quantifying the extent of lung damage and in directing treatment. The aim of this review is(More)
BACKGROUND CT pulmonary angiography (CTPA) is an increasingly popular imaging test for assessing patients with acute chest pain. PURPOSE To evaluate the number of CTPA performed in 2009 compared with 2006 and assess the frequency of pulmonary embolus (PE) versus alternative diagnoses. MATERIAL AND METHODS Numbers of CTPA and V/Q scans performed in a(More)
OBJECTIVES To compare the diagnostic performance of clinical assessment against magnetic resonance imaging (MRI) diagnosed hip arthritis in a juvenile idiopathic arthritis (JIA) population. To determine the clinical and serological predictors of MRI diagnosed hip arthritis. METHODS A total of 34 JIA patients with established disease (mean disease duration(More)
Pulmonary cysts, cavities, and honeycombing are seen in a number of systemic disorders. The purpose of this review is to discuss the findings on thin-section computed tomography (CT) in both congenital and acquired multisystem conditions that give rise to multiple cystic spaces in the lungs. Conditions discussed include lymphangioleiomyomatosis, Langerhan's(More)
OBJECTIVE We evaluated the reliability of various multidetector computed tomography (MDCT) parameters for diagnosis and severity assessment of pulmonary hypertension (PH) with consideration of World Health Organization (WHO) classification. METHODS A total of 172 patients were included in this retrospective study. One hundred fourteen patients had a(More)
Neutrophils are the most abundant circulating white cell in humans and play a crucial role in the innate immune response. Accumulation and activation of neutrophils, together with delayed clearance, have been shown to be a key event in the pathogenesis of acute lung injury. Previously, it has been proposed that there is substantial pooling of neutrophils(More)
This report concerns a 67 year old male patient with known advanced relapsing polychondritis complicated by tracheobronchial chondromalacia who is increasingly symptomatic and therapeutic options such as tracheostomy and stenting procedures are being considered. The DICOM files from the patient's dynamic chest CT in its inspiratory and expiratory phases(More)
The purpose of this article is to educate the reader in the value a radiologist can offer in the multidetector (MD) CT assessment of patients with chronic obstructive pulmonary disease (COPD). MDCT can identify patients in whom treatments such as lung volume reduction surgery or newer endobronchial therapies may be of benefit. We will also discuss important(More)