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- Klarisa Rikova, Ailan Guo, +27 authors Michael Comb
- Cell
- 2007
Despite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our ability to identify drug targets and… (More)
MicroRNAs are endogenous ∼23-nucleotide RNAs that can pair to sites in the messenger RNAs of protein-coding genes to downregulate the expression from these messages. MicroRNAs are known to influence… (More)
- Sean A Beausoleil, Mark Jedrychowski, +6 authors Steven P Gygi
- Proceedings of the National Academy of Sciences…
- 2004
Determining the site of a regulatory phosphorylation event is often essential for elucidating specific kinase-substrate relationships, providing a handle for understanding essential signaling… (More)
- Maria K Lehtinen, Zengqiang Yuan, +7 authors Azad Bonni
- Cell
- 2006
Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, we demonstrate that the protein… (More)
- Noah Dephoure, Chunshui Zhou, +4 authors Steven P Gygi
- Proceedings of the National Academy of Sciences…
- 2008
The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all cellular material into two newly formed… (More)
- Eric Lieberman Greer, Dara P Dowlatshahi, +5 authors Anne Brunet
- Current Biology
- 2007
BACKGROUND
Dietary restriction (DR) is the most effective environmental intervention to extend lifespan in a wide range of species. However, the molecular mechanisms underlying the benefits of DR on… (More)
- Edward L. Huttlin, Mark P. Jedrychowski, +7 authors Steven P Gygi
- Cell
- 2010
Although most tissues in an organism are genetically identical, the biochemistry of each is optimized to fulfill its unique physiological roles, with important consequences for human health and… (More)
- Sean A Beausoleil, Judit Villén, Scott A. Gerber, John V. Rush, Steven P Gygi
- Nature Biotechnology
- 2006
Data analysis and interpretation remain major logistical challenges when attempting to identify large numbers of protein phosphorylation sites by nanoscale reverse-phase liquid chromatography/tandem… (More)
- Pavel Ivanov, Mohamed Moheeb Emara, Judit Villén, Steven P Gygi, Paul N. Anderson
- Molecular cell
- 2011
Angiogenin is a stress-activated ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs). Transfection of natural or synthetic tiRNAs inhibits… (More)
- Judit Villén, Sean A Beausoleil, Scott A. Gerber, Steven P Gygi
- Proceedings of the National Academy of Sciences…
- 2007
Protein phosphorylation is a complex network of signaling and regulatory events that affects virtually every cellular process. Our understanding of the nature of this network as a whole remains… (More)