The aim of our study was to establish the contribution of distinct pathological aggregates (cortical Lewy bodies (LB), neuronal tau-inclusions and β-amyloid plaque (Aβ) deposition) in dementia related to Parkinson's disease (PD) in a large autopsy cohort. We studied the brains of 155 PD patients, 109 of whom were clinically demented. The total LB score, the… (More)
OBJECTIVES Most patients with anti-NMDA receptor (NMDAR) encephalitis have intrathecal synthesis of antibodies, which cause a decrease of cell surface and synaptic NMDAR. Antibodies are immunoglobulin G (IgG)1 and IgG3 subtypes and can potentially activate complement. We examined whether complement immunoreactivity and antibody-secreting cells (plasma… (More)
RATIONALE Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by recurrent infections of the airways and situs inversus in half of the affected offspring. The most frequent genetic defects comprise recessive mutations of DNAH5 and DNAI1, which encode outer dynein arm (ODA) components. Diagnosis of PCD usually relies on… (More)
Alzheimer's disease is characterized by the presence of senile plaques in the brain, composed mainly of aggregated amyloid-beta peptide (Abeta), which plays a central role in the pathogenesis of Alzheimer's disease and is a potential target for therapeutic intervention. Amyloid plaques occur in an increasing number of brain structures during the progression… (More)
The spectrum of Lewy body disorders includes not only Parkinson's disease, dementia with Lewy bodies and Parkinson's disease associated dementia but also Lewy body dysphagia and autonomic failure with Lewy bodies. In the last years an increasing number of cases showing Lewy body pathology has been recognised at autopsy. In fact, dementia with Lewy bodies is… (More)
BACKGROUND In the third season of I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe), we undertook a multicentre case-control study based on sentinel practitioner surveillance networks in eight European Union (EU) member states to estimate 2010/11 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI)… (More)
BACKGROUND Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis has been recently reported as autoimmune/paraneoplastic encephalitis, affecting mostly young females. OBJECTIVE To describe opsoclonus-myoclonus syndrome in association with anti-NMDAR antibodies. DESIGN Case report. SETTING Geneva University Hospital. Patient A 23-year-old woman… (More)
Thanks also to the TESSy team and other experts from the Surveillance section for their continued support and to Per Rolfhamre, Gaetan Guyodo, Silvia Sarbu, Catalin Albu and Valentina Lazdina for data management and providing technical support to the participating countries.