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Journals and Conferences
OBJECTIVE To evaluate the efficacy and safety of apremilast, a novel, orally available small molecule that specifically targets phosphodiesterase 4, in the treatment of active psoriatic arthritis (PsA). METHODS This phase II, multicenter, randomized, double-blind, placebo-controlled study included the following: a 12-week treatment phase, with patients… (More)
OBJECTIVE Infliximab (IFX) is a therapeutic monoclonal antibody targeting tumor necrosis factor-α indicated in the treatment of chronic inflammatory diseases. IFX is administered by intravenous infusion and may be associated with different types of infusion reactions. METHODS RemiTRAC Infusion (NCT00723905) is a Canadian observational registry in which… (More)
We report a patient with longstanding rheumatoid arthritis (RA) who developed pure red cell aplasia. This condition is a rare complication of RA. Our patient recovered, apparently in response to treatment with corticosteroids and cyclophosphamide followed by azathioprine.
Current treatment guidelines advocate opioids for arthritis when standard analgesics produce inadequate relief. Efficacy, adverse effects (AEs), dosing regimens, physician expertise and patient preference influence treatment selection. This study assessed transdermal fentanyl (TDF) as a treatment option for osteoarthritis (OA) patients. This prospective,… (More)
Objective. Infliximab (IFX) is a therapeutic monoclonal antibody targeting tumor necrosis factor-a indicated in the treatment of chronic inflammatory diseases. IFX is administered by intravenous infusion and may be associated with different types of infusion reactions. Methods. RemiTRAC Infusion (NCT00723905) is a Canadian observational registry in which… (More)
OBJECTIVE To describe the rate of concomitant oral corticosteroid use at antitumour necrosis factor (TNF) initiation and at disease remission, and to assess its effect on incidence of infection and sustainability of remission among patients with rheumatoid arthritis (RA) treated with infliximab in Canadian routine care. METHODS Biological naïve patients… (More)
We report a patient with bilateral vocal cord paralysis and upper airway obstruction following Guillain-Barré syndrome (GBS). A permanent tracheostomy was necessary to maintain adequate ventilation and to prevent alveolar hypoventilation. Despite abduction paralysis, the patient talks normally.