Learn More
The ethanolic leaf extract of Heinsia crinata, grown particularly for the leaf in Niger Delta region of Nigeria, was evaluated for antiplasmodial activity in Plasmodium berghei-infected mice as well as for hypoglycemic and antidiabetic activities in alloxan-induced diabetic rats. H. crinata (450-1,350 mg/kg/day) exhibited significant (P < .05) blood(More)
OBJECTIVE To evaluate the antidiabetic activities of ethanolic root extract/fraction of Anthocleista djalonensis (A. djalonensis) in alloxan-induced diabetic rats. METHODS A. djalonensis root extract/fractions (37-111 mg/kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels (BGLs) of the diabetic rats were monitored(More)
The antimalarial activities of ethanolic root extracts of two plants used traditionally as malarial remedies in southern Nigeria, Uvaria chamae (Annonaceae) and Hippocratea africana (Hippocrateaceae), were studied in vivo, in mice infected with Plasmodium berghei berghei. The extract of U. chamae, when given orally at 300-900 mg/kg.day, exhibited(More)
The antimalarial activity of an ethanol leaf extract of Setaria megaphylla was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections. Setaria megaphylla (100-300 mg/kg/day) exhibited a significant (p < 0.05) blood schizonticidal activity in 4-day early infection and in established infection with a(More)
OBJECTIVE To evaluate the antidiabetic and hypolipidemic activities of ethanolic leaf extract and fraction of Melanthera scandens (M. scandens) in alloxan-induced diabetic rats. METHODS M. scandens leaf extract/fractions (37-111 mg/kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels (BGL) of the diabetic rats were(More)
OBJECTIVE Antiplasmodial and analgesic activities of the leaf extract and fractions of Clausena anisata (C. anisata) were evaluated for antimalarial and analgesic activities. METHODS The crude leaf extract (39-117 mg/kg) and fractions (chloroform and acqeous; 78 mg/kg) of C. anisata were investigated for antiplasmodial activity against(More)
Carpolobia lutea (leaves and root) is used traditionally as malarial remedy by the Ibibios of Niger Delta of Nigeria and Benin. This study was aimed to investigate the antiplasmodial potentials of the crude leaf and root extracts of this plant as well as their fractions in vivo in Plasmodium berghei berghei-infected mice to give scientific proof to the(More)
AIM OF THE STUDY Antiplasmodial activity of root extract and fractions of Croton zambesicus were evaluated to ascertain the folkloric claim of its antimalarial activity and elucidate its antiplasmodial mechanism of action. MATERIAL AND METHOD The crude ethanolic root extract (27-81 mg/kg) and gradient fractions (n- hexane, chloroform, ethyl acetate and(More)
Ethanolic leaf extract of Croton zambesicus was administered to rats at doses of 100 – 400mg / kg for 21 days to investigate its effect on the haematological indices of rats. Haematological indices, namely packed cell volume (PCV), Haemoglobin concentration (Hb) Red blood cell count (RBC), Mean cell Haemoglobin concentration (MCHC), Mean cell volume (MCV),(More)
CONTEXT Hippocratea africana (Willd.) Loes. ex Engl. (Celastraceae) root is used traditionally as an antipoison or antidote to treat liver diseases. OBJECTIVE To evaluate antioxidative burst and hepatoprotective potentials of H. africana against paracetamol-induced liver injury in rats. MATERIALS AND METHOD Antioxidative burst activity of the extract(More)