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BACKGROUND Numerous studies have demonstrated the existence of stable regulatory RNAs, microRNAs (miRNAs), in the circulation and have shown that the spectrum of these extracellular miRNAs is affected by various pathologic conditions including cancers. CONTENT Circulating miRNAs have been the focus of numerous cancer biomarker discovery efforts over the… (More)
MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated… (More)
By replacing the distances between pairs of vertices with the relative distances, we define a novel valence overall Wiener index (VOW); the valence overall Wiener index extends the usefulness of the Wiener index and the overall Wiener index to unsaturated hydrocarbons.