Juan Yuan

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UNLABELLED : Huntington's disease (HD) results from a CAG repeat expansion in the gene encoding the huntingtin protein. This inherited disorder is characterized by progressive neurodegeneration. In particular, HD progression involves the loss of striatal projection neurons. The limited availability of reliable sources of human striatal projection neurons(More)
The binding mechanisms of the interaction of three dihydromyricetin (DMY)Àmetal complexes (DMYÀCu (II) complex, DMYÀMn (II) complex, DMYÀZn (II) complex) and DMY with bovine serum albumin (BSA) were investigated using fluorescence and ultraviolet spectroscopy at different temperatures. The results indicated some differences in the binding process between(More)
The c-Jun N-terminal kinases (JNKs), serine/threonine protein kinases including three isoforms: JNK1, JNK2, and JNK3 are attractive targets for the treatment of neurodegenerative disorders. Many reported JNKs inhibitors could prevent neuronal degradation, but most exist with selective vulnerability to toxic effects. In this paper, we had applied a combined(More)
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