Juan Yuan

Learn More
UNLABELLED : Huntington's disease (HD) results from a CAG repeat expansion in the gene encoding the huntingtin protein. This inherited disorder is characterized by progressive neurodegeneration. In particular, HD progression involves the loss of striatal projection neurons. The limited availability of reliable sources of human striatal projection neurons(More)
The binding mechanisms of the interaction of three dihydromyricetin (DMY)Àmetal complexes (DMYÀCu (II) complex, DMYÀMn (II) complex, DMYÀZn (II) complex) and DMY with bovine serum albumin (BSA) were investigated using fluorescence and ultraviolet spectroscopy at different temperatures. The results indicated some differences in the binding process between(More)
The c-Jun N-terminal kinases (JNKs), serine/threonine protein kinases including three isoforms: JNK1, JNK2, and JNK3 are attractive targets for the treatment of neurodegenerative disorders. Many reported JNKs inhibitors could prevent neuronal degradation, but most exist with selective vulnerability to toxic effects. In this paper, we had applied a combined(More)
In the title complex, [CdCl(2)(C(11)H(10)N(4))(2)(H(2)O)(2)]·6H(2)O, the Cd(II) atom is located on a twofold rotation axis and is coordinated by two N atoms from two 1-[(1H-benzimidazol-2-yl)meth-yl]-1H-imidazole ligands and two water O atoms in equatorial positions and by two Cl atoms in axial positions, leading to an elongated octa-hedral environment. The(More)
Aiming at the former formalized methods such as Strips, Situation Calculus and Fluent Calculus can not represent the action time and get the action sequence automatically, a novel method based on timed color Petri net—RPBTC was defined. The action time, the precondition and the post-condition of action are formalized in RPBTC based on the Fluent Calculus(More)
In the title complex, [Co(C(6)H(14)NO(3))(N(3))] or [Co(teaH(2))N(3)], the Co(II) atom resides in a trigonal-bipymidal O(3)N(2) environment formed by three O atoms and one N atom from a simply deprotonated tetra-dentate triethano-lamine ligand, and one N atom from an azide ligand. The O atoms define the equatorial plane whereas both N atoms are in axial(More)
  • 1