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Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress
TLDR
The results provide evidence for antidepressant-like and anxiolytic-like effects of H2S in STZ-induced diabetic rats and suggest that the therapeutic effects may result from inhibition of hippocampal oxidative stress. Expand
Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
TLDR
Treatment of diabetic rats with sodium hydrosulfide (NaHS, a donor of H2S, 30 or 100 μmol/kg/d, for 30 d) significantly reversed diabetes-induced impairment in cognitive function, suggesting that H2 S exhibits therapeutic potential for diabetes-associated cognitive dysfunction, which is likely related to its protective effects against hippocampal ER stress. Expand
Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress.
TLDR
Treatment of diabetic rats with sodium hydrosulfide (NaHS, a donor of H2S, 30 or 100 μmol/kg/d, for 30 d) significantly reversed diabetes-induced impairment in cognitive function, suggesting that H2 S exhibits therapeutic potential for diabetes-associated cognitive dysfunction, which is likely related to its protective effects against hippocampal ER stress. Expand
[Influence of Moxibustion on TLR 4-MyD 88-NF-KB Signal Transduction Pathway of Synovial Tissue in Rheumatoid Arthritis Rats].
TLDR
Moxibustion intervention can improve pathological changes of the knee-joint synovial membrane tissue in RA rats, which may be related with its effect in inhibiting abnormal activation of TLR 4-MyD 88-NF-κB pathway insynovial tissue. Expand
[Effects of Moxibustion on Expression of STAT 1, SOCS mRNA in Synovium of Rats with Rheumatoid Arthritis].
TLDR
Moxibustion achieves the effects of anti-inflammation and joint swelling reduction of RA via decrease ofIL-1, increase of IL-2 in serum and up-regulation of STAT 1, SOCS mRNA expression in synovium. Expand
[Toll-like Receptor 4/Nuclear Factor-κB Signaling in Synovial Tissue Is Involved in the Anti-inflammatory Effect of Moxibustion in Rats with Rheumatoid Arthritis].
TLDR
Moxibustion can reduce the ankle joint swelling in RA rats, which may be closely associated with its effect in down-regulating the expression of IκB, and activation of TLR 4 reduced the anti-inflammatory effect of moxibUSTion intervention. Expand