Juan Wen

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Androgen deprivation therapy of prostate cancer with estrogens shows significant cardiovascular side-effects. To develop effective prostate cancer therapeutic agent(s) with minimal cardiovascular side-effects, we compared the effects of various estrogen receptor (ER) ligands on the modulation of dihydrotestosterone (DHT) actions in LAPC-4 and LNCaP prostate(More)
BACKGROUND Recently, several studies have demonstrated that two long non-coding RNAs (lncRNAs), HULC and MALAT1, may participate in hepatocellular carcinoma (HCC) development and progression. However, genetic variations in the two lncRNAs and their associations with HCC susceptibility have not been reported. In this study, we hypothesized that single(More)
BACKGROUND MiR-106b-25 cluster, hosted in intron 13 of MCM7, may play integral roles in diverse processes including immune response and tumorigenesis. A single nucleotide polymorphism (SNP), rs999885, is located in the promoter region of MCM7. METHODS We performed a case-control study including 1300 HBV-positive hepatocellular carcinoma (HCC) cases, 1344(More)
Excessive mechanical loads on the temporomandibular joint (TMJ) can cause mandibular cartilage degradation and subchondral bone erosion, but the treatment of these conditions remains challenging. Salubrinal, which target eukaryotic translation initiation factor 2 alpha, has been shown to have multiple beneficial effects on skeletal tissue. Here, we examined(More)
—In heterogeneous cellular networks (HCNs), the interference received at a user is correlated over time slots since it comes from the same set of randomly located BSs. This results in the correlations of link successes, thus affecting network performance. Under the assumptions of a K-tier Poisson network, strongest-candidate based BS association, and(More)
We have participated in three open tracks of Chinese word segmentation and named entity recognition tasks of SIGHAN Bakeoff3. We take a probabilistic feature based Maximum Entropy (ME) model as our basic frame to combine multiple sources of knowledge. Our named entity recognizer achieved the highest F measure for MSRA, and word segmenter achieved the medium(More)
In this paper, we consider the local discontinuous Galerkin (LDG) finite element method for one-dimensional linear time-fractional Tricomi-type equation (TFTTE), which is obtained from the standard one-dimensional linear Tricomi-type equation by replacing the first-order time derivative with a fractional derivative (of order α, with 1 < α ≤ 2). The proposed(More)
Combined therapy emerges as an attractive strategy for cancer treatment. The aim of this study was to investigate the inhibitory effects of mitomycin C (MMC) combined with a novel antibody fragment (Fab) targeting latent membrane protein 1 (LMP1) on nasopharyngeal carcinoma (NPC) xenograft nude mice. The inhibitory rates of MMC (2 mg/kg), Fab (4 mg/kg), MMC(More)