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A set of different protein kinases have been involved in tau phosphorylations, including glycogen synthase kinase 3beta (GSK3 beta), MARK kinase, MAP kinase, the cyclin-dependent kinase 5 (Cdk5) system and others. The latter system include the catalytic component Cdk5 and the regulatory proteins p35, p25 and p39. Cdk5 and its neuron-specific activator p35(More)
Alzheimer's disease, the cause of one of the most common types of dementia, is a brain disorder affecting the elderly and is characterized by the formation of two main protein aggregates: senile plaques and neurofibrillary tangles, which are involved in the process leading to progressive neuronal degeneration and death. Neurodegeneration in Alzheimer's(More)
The cdk5 and its activator p35 constitute one of the main tau-phosphorylating systems in neuronal cells. Under normal conditions for neurons, its activity is required for modulating tau involvement in neuronal polarity and in development of the mammalian central nervous system. Recently, we reported that the treatment of rat hippocampal cells in culture(More)
Cytoskeleton organization is sensitive to regulatory signals at both spatial and temporal levels. In differentiating neurons, regulation of cell architecture is specially relevant, and tau plays a major role in the outgrowth of neurites and axonal development. Tau activity in determining neuronal polarity is modulated by protein kinases including cdk5. A(More)
Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal mitochondria are fragmented, but the mechanism underlying this process is poorly understood. Here, we show that Mfn2 is the only member of the mitochondrial fusion/fission machinery whose expression(More)
In this workshop paper, we share the design and on-going implementation of our HRTeam framework, which is constructed to support multiple robots working with a human operator in a dynamic environment. The team is comprised of one human plus a heterogeneous set of inexpensive, limited-function robots. Although each individual robot has restricted mobility(More)
Within the context of human/multi-robot teams, the " help me help you " paradigm offers different opportunities. A team of robots can help a human operator accomplish a goal, and a human operator can help a team of robots accomplish the same, or a different, goal. Two scenarios are examined here. First, a team of robots helps a human operator search a(More)
The heterogeneous family of tau proteins interacts with microtubules, actin filaments, and intermediate filaments. The tau isoforms have been shown to play a major role in neuronal polarity. However, tau-like proteins have been found in several other types of cells. Previous studies have also indicated the presence of a nuclear tau. The relationships(More)
This extended abstract briefly describes a new methodology for shared decision-making in human/multi-robot teams. We present a new application of FORR, a cognitive architecture that considers the opinions of others when choosing actions. While robots in our system ultimately make their own decisions about their actions, they do so based on collective advice(More)
Our research involves application of methods well-studied in virtual multiagent systems (MAS) but less well-understood in physical multi-robot systems (MRS). This paper investigates the relationship between performance results collected in parallel simulated (multiagent) and physical (multi-robot) environments. Our hypothesis is that some performance(More)