Juan Oliver

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Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then form nephrons. Purification and(More)
This paper describes a distributed software architecture designed to manage, in an integrated way, interoperable Smart-Grid networks. It has been designed to address the fact of having massive deployments of AMI, DA, and HAN devices (meters, concentrators, sensors) from multiple vendor technologies, which must be accessed through several communications(More)
BACKGROUND Hypovolemic shock of marked severity and duration may progress to cardiovascular collapse unresponsive to volume replacement and drug intervention. On the basis of clinical observations, we investigated the action of vasopressin in an animal model of this condition. METHODS AND RESULTS In 7 dogs, prolonged hemorrhagic shock (mean arterial(More)
Thrombin can activate factor XI in the presence of dextran sulfate or sulfatides. However, a physiological cofactor for thrombin activation of factor XI has not been identified. We examined this question in a cell-based, tissue factor-initiated model system. In the absence of factor XII, factor XI enhanced thrombin generation in this model. The effect on(More)
Since plasma endothelin concentration increases with upright posture and decreases with volume expansion, a study was conducted to test whether activation of the baroreceptor reflex releases endothelin into plasma. The effect of passive upright tilt on the plasma concentrations of endothelin and vasopressin was examined in: (1) normal subjects; (2) patients(More)
The mechanism whereby the vasoconstrictor response to angiotensin II (AII) is influenced by sodium balance or disease is unclear. To explore this question, the renal vascular responses (RVR) to intrarenal injections of subpressor doses of AII and norepinephrine were studied in dogs with an electromagnetic flowmeter. Acute and chronic sodium depletion(More)
SUMMARY The present study was designed to determine whether renal prostaglandins are involved in the renal vasodilation evoked by angiotensin II inhibition in sodium depletion. The converting enzyme inhibitor (CEI) captopril was administered to sodium-depleted control dogs and sodium-depleted dogs that had previously received the inhibitors of prostaglandin(More)
Background. Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II type 1 receptor blockers (ARB) decrease cardiovascular mortality and slow the progression of renal disease in non-transplant patients, but their impact on kidney transplant outcome has not been well established. were considered for the present study. Only adult (≥18 years)(More)
The huge computational complexities involved with particle filters is known to be one of the major constraint to their widespread use for different real time applications. This paper analyzes the computational complexities of the sampling, importance weight and resampling steps for the two most popular types of particle filters; generic particle filter and(More)
To determine whether adult kidney papillary label-retaining cells (pLRCs) are specialized precursors, we analyzed their transcription profile. Among genes overexpressed in pLRCs, we selected candidate genes to perform qPCR and immunodetection of their encoded proteins. We found that Zfyve27, which encodes protrudin, identified a subpopulation of pLRCs. With(More)