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OBJECTIVE Using a mouse model, Iron Overload (IO) induced bone marrow microenvironment injury was investigated, focusing on the involvement of reactive oxygen species (ROS). METHODS Mice were intraperitoneally injected with iron dextran (12.5, 25, or 50 mg) every three days for two, four, and six week durations. Deferasirox(DFX)125 mg/ml and(More)
Iron overload, caused by hereditary hemochromatosis or repeated blood transfusions in some diseases, such as beta thalassemia, bone marrow failure and myelodysplastic syndrome, can significantly induce injured bone marrow (BM) function as well as parenchyma organ dysfunctions. However, the effect of iron overload and its mechanism remain elusive. In this(More)
The iron-overload mouse model used in this study was previously reported by the authors in references 1 and 2, which are not cited in the Article. The data supporting the mouse model is presented in Figure 1 of the Article. The data presented in in Figure 1b appear in reference 1 as Figure 1b; and the data presented in Figure 1c appear in reference 1 as(More)
Stripe rust (or yellow rust), caused by Puccinia striiformis f. sp. tritici (Pst), is a devastating fungal disease of common wheat. Wheat line P9897 showed adult-plant resistance (APR) to stripe rust for several years. To map resistance quantitative trait loci (QTL), F2:3 lines from a cross of P9897 with susceptible Mingxiang 169 were phenotyped for stripe(More)
Resumen Durante muchos años la mejora de los procesos de desarrollo y mantenimiento de software se ha estudiado desde un punto de vista de ingeniería, con la premisa de que un mejor proceso de desarrollo permite la construcción de mejores productos. En este contexto son bien conocidos modelos de madurez como CMM, CMMI, ISO/IEC 15504 o ISO 9001:2000. Más(More)
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