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  • Auger Collaboration, J Abraham, M Aglietta, I C Aguirre, M Albrow, D Allard +358 others
  • 2004
Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observatory is to collect unprecedented information about cosmic rays above 10 18 eV: The first phase of the project, the construction and operation of a prototype system, known as the engineering array, has now been completed. It has allowed all of the subsystems that(More)
Identifying small groups of lines, whose removal would cause a severe blackout, is critical for the secure operation of the electric power grid. We show how power grid vulnerability analysis can be studied as a bilevel mixed integer nonlinear programming problem. Our analysis reveals a special structure in the formulation that can be exploited to avoid(More)
An important a r e a of research in computational biochemistry is the design of molecules for speciic applications. The design of these molecules, which depends on the accurate determination of their three-dimensional structure, can beformulated as a global optimization problem. In this study, we present results from the application of a new conformation(More)
The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is key to overcoming this challenge. Here we present a data-driven mathematical approach for developing antibiotic treatment(More)
The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is key to overcoming this challenge. Here we present a data-driven mathematical approach for developing antibiotic treatment(More)
Over the past two decades the field of computational science and engineering (CSE) has penetrated both basic and applied research in academia, industry, and laboratories to advance discovery, optimize systems, support decision-makers, and educate the scientific and engineering workforce. Informed by centuries of theory and experiment , CSE performs(More)