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The incidence of gastrinomas is 0.5–3/million population/ year. They are the most common functional and, malignant pan-creatic endocrine tumor (PET) syndrome and comprise up to 30% of these tumors [3, 4]. Duodenal tumors, which were originally thought to be uncommon (i.e. ! 20%), now make up 50–88% of gastrinomas in sporadic ZES patients and 70–100% of(More)
Performance of 5-HIAA in Diagnosis The overall sensitivity and specificity of urinary 5-HIAA in the presence of the carcinoid syndrome is of the order of 70 and 90%, respectively [1, 2]. Midgut carcinoids are most liable to produce the carcinoid syndrome with 5-HIAA elevation, thus attesting to a high specificity (1 90%) in this setting. Fore-and hindgut(More)
BACKGROUND The non-surgical management in a selected group of rectal cancer patients has shown promising results with adequate follow up. AIMS describing the results of the non-surgical management in patients with complete clinical response, with a close follow up. METHODS Between 2006 and 2015, patients with rectal cancer, stages I-III, without(More)
Elevated circulating levels of chromogranin A (CgA) are found in the neuroendocrine tumors (NETs), but diagnostic usefulness of this marker is still debatable. To assess the role of CgA for the identification and follow up of gastroenteropancreatic neuroendocrine tumors (GEP-NET), a multicenter prospective longitudinal study has been carried out in(More)
INTRODUCTION Somatostatin receptors are expressed in a large number of human tumours. The somatostatin receptors types 1-5 expression in a series including 100 gastro-entero-pancreatic endocrine tumours were analysed. METHODS From a prospectively built database of patients with gastro-entero-pancreatic endocrine tumours referred from three institutions,(More)
A panel of experts from Latin America convened in Brazil, in May of 2007, for consensus recommendations regarding the management of neuroendocrine tumors (NETs) of the gastrointestinal tract and pancreas. The recently introduced World Health Organization classification of NETs represents a step forward, but the former classification of carcinoids into(More)