Juan Manuel Mancilla-Díaz

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BACKGROUND Feeding behavior is deeply affected by serotonergic neurotransmission. This regulatory activity is mediated mainly by specific 5-HT1/2 receptors, and the paraventricular nucleus (PVN) plays a key role in this phenomena. In order to reveal the involvement of 5-HT1A and 5-HT1B receptors in the paraventricular nucleus of the hypothalamus (PVN) on(More)
The present study examined the effects of 5-HT1A and 5-HT2C receptor agonists on behavioral satiety sequence (BSS) in rats. The 5-HT1A receptor agonist, 8-OH-DPAT (0.5 microg), and the 5-HT2C receptor agonist, Ro-60-0175 (3.0 microg), were injected into the paraventricular nucleus (PVN) of rats. The animals were maintained on an ad libitum feeding paradigm(More)
It has been shown that endogenous and exogenous cannabinoids substantially increase feeding. Despite evidence for a role of endocannabinoids in mediating food ingestion, the mechanisms by which CB1 receptor agonists and antagonists have an effect on motivational processes (hunger, satiety) as well as on specific food preference are not entirely understood.(More)
Obesity is a serious worldwide health problem, affecting 20-40% of the population in several countries. According to animal models, obesity is related to changes in the expression of proteins that control energy homeostasis and in neurotransmission associated to regulation of food intake. For example, it has been reported that diet-induced obesity produces(More)
This study refers to the evaluation of the psychometric properties of the Drive for Muscularity Scale among Mexican population. The exploratory factor analysis was carried out with 369 university males (mean age = 20.93 years). A three-factor structure that explains 45.64 % of the variance was found for the scale: 31.10 % by attitudes (α = 0.87), 10.70 % by(More)
The present study examined the effects of intra-PVN serotonin injection in mianserin-pretreated rats at the onset of the dark phase of light cycle on the structure of feeding behavior. The drugs were injected into the paraventricular nucleus (PVN) of the hypothalamus. The animals were maintained in a self-selection feeding paradigm and provided with freely(More)
The aim of this study was to assess eating behaviours and attitudes in a community sample of 615 adolescent Mexican students recruited at a middle school (192 boys and 226 girls; mean age +/- standard deviation 13.56+/-0.09) and high school (90 boys and 107 girls; mean age 16.04+/-0.12 years), who completed the Eating Attitudes Test (EAT), the Bulimia Test(More)
We examined the effects of 5-HT on the feeding behaviour patterns of rats pretreated with mianserin (5-HT(1B/2A/1D receptor antagonist) or cyproheptadine (a 5-HT(2c) receptor antagonist), injected into the pariventricular hypothalamus nucleus (PVN). The animals were kept at 21 +/- 1 degrees C with a 12 h light and 12 h dark cycle on a self-selected feeding(More)
Obesity and its related pathologies are well-known health hazards. Although obesity and overweight have multifactorial causes, overeating is common in both of these conditions. According to animal models, endocannabinoids and their receptors in the brain play a key role in the genesis and development of obesity. It has been proposed that the cannabinoid(More)
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