Juan Manuel Fernández

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Strontium ranelate (SR) is an orally administered and bone-targeting anti-osteoporotic agent that increases osteoblast-mediated bone formation while decreasing osteoclastic bone resorption, and thus reduces the risk of vertebral and femoral bone fractures in postmenopausal women with osteoporosis. Osteoblastic alkaline phosphatase (ALP) is a key enzyme(More)
We have previously demonstrated that renal cortical collecting duct cells (RCCD(1)), responded to hypotonic stress with a rapid activation of regulatory volume decrease (RVD) mechanisms. This process requires the presence of the water channel AQP2 and calcium influx, opening the question about the molecular identity of this calcium entry path. Since the(More)
Hydroxyapatite (HAP)-containing poly-ε-caprolactone (PCL)-polydiisopropyl fumarate (PDIPF) composite (Blend) was developed as an alternative for bone tissue engineering. The physicochemical, mechanical and biocompatibility properties of these composites were evaluated using two osteoblast-like cell lines (UMR106 and MC3T3E1) and compared with the blend(More)
NMO-IgG autoantibody selectively binds to aquaporin-4 (AQP4), the most abundant water channel in the central nervous system and is now considered a useful serum biomarker of neuromyelitis optica (NMO). A series of clinical and pathological observations suggests that NMO-IgG may play a central role in NMO physiopathology. The current study evaluated, in(More)
Authors: Marieke De Craemer (marieke.decraemer@ugent.be) Ellen De Decker (ellen.dedecker@ugent.be) Ilse De Bourdeaudhuij (ilse.debourdeaudhuij@ugent.be) Benedicte Deforche (benedicte.deforche@ugent.be) Carine Vereecken (carine.vereecken@ugent.be) Kristin Duvinage Kamila Zych (kamila_zych@op.pl) Yannis Manios (manios@hua.gr) Greet Cardon(More)
BACKGROUND INFORMATION A major hallmark of apoptosis is cell shrinkage, termed apoptotic volume decrease, due to the cellular outflow of potassium and chloride ions, followed by osmotically obliged water. In many cells, the ionic pathways triggered during the apoptotic volume decrease may be similar to that observed during a regulatory volume decrease(More)
Assistive technologies need to constantly adapt and react to user needs. To this end, ambient intelligence techniques could be adopted. One approach consists of defining suitable rules to trigger actions or suggestions to the users. In this paper, ATML (Ambient intelligence Trigger Markup Language), a novel suitable language, is presented and described.(More)
We have previously demonstrated that in renal cortical collecting duct cells (RCCD(1)) the expression of the water channel Aquaporin 2 (AQP2) raises the rate of cell proliferation. In this study, we investigated the mechanisms involved in this process, focusing on the putative link between AQP2 expression, cell volume changes, and regulatory volume decrease(More)
The access to the Universities studies is one of the most important steps to obtain a total integration of the people with disabilities. Spanish laws about Web Accessibility, force to the public institutions, including Universities, to accomplish the basic normative WCAG since 2002. In this paper we present a study of the accessibility on the Spanish(More)
People going back to home after a discharge needs to come back to their normal life. Unfortunately, it becomes very difficult for people with severe disabilities, such as a traumatic brain injury. Thus, this kind of users needs, from the one hand, a telemonitoring system that allows therapists and caregivers to be aware about their status and, from the(More)