Juan Manuel Durán

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BACKGROUND Myocardial reperfusion is associated with calcium overload and cell contracture, mechanisms that may precipitate cell death. In this study, we tested the hypothesis that in vivo inhibition of this contracture could lead to cell preservation in an open-chest large animal model. METHODS AND RESULTS Regional myocardium function was measured during(More)
Myocardial water content and infarct size were studied in 39 pigs randomly assigned to a nonintervention group, a group with an intracoronary infusion of a control solution, and a group with a hyperosmotic infusion to 450 mosM by the addition of D-mannitol. The intracoronary solutions were selectively infused into the left anterior descending coronary(More)
It has been estimated that 15-25% of patients who undergo percutaneous or surgical coronary angioplasty are diabetics. The indications for coronary revascularization and initial results of the procedure do not differ substantially between patients with diabetes mellitus and non-diabetics. However, the long-term results of both percutaneous and surgical(More)
INTRODUCTION AND OBJECTIVES Experimental and clinical studies suggest that necrotic myocardium may have the capacity to regenerate. We have started a clinical study to demonstrate that the intracoronary implantation of stem cells is feasible and safe. The results in our first 5 patients are presented here. PATIENTS AND METHOD We included patients with(More)
OBJECTIVE The objective of this study was to compare the initial and long-term outcome of elderly and younger patients after coronary stent implantation. METHODS The evolutions of 76 patients aged >75 years and of 860 patients aged < or =75 years who underwent consecutive stenting (from June 1991 to June 1997) were compared in a cohort study. RESULTS(More)
OBJECTIVES We sought to analyze right ventricular contractility during dobutamine infusion in patients with right coronary artery disease and to elucidate whether the development of right ventricular asynergy aids in characterizing a right coronary artery stenosis. BACKGROUND Clinical investigations are emphasizing the importance of right ventricular(More)
Calcium antagonists are the treatment of choice in vasospasm angina when no stenosis or mild stenosis are present. We present a case in which ergonovine echocardiography showed vasospasm of the right coronary artery despite optimal medical treatment. Stenting of a mild stenosis in that artery successfully controlled vasospasm and a pre-discharge ergonovine(More)
OBJECTIVES This study was designed to evaluate the effect of an antithrombotic regimen without full early anticoagulation on subacute occlusion, bleeding, hospital stay and restenosis after elective coronary stenting. BACKGROUND Subacute occlusion is a major limitation of stenting. Aggressive antithrombotic therapy is not fully prophylactic against this(More)
some of them. There is some hope for therapy of acute and diastolic heart failure. Progress in cardiac surgery and valve interventions still await prove of their relevance for the course of heart failure. It has become clearer which patients benefit from heart failure management programmes. Competing concepts of cell therapy seem to spiral, hopefully(More)
Rev Esp Cardiol 2003;56(1):99 99 A 70 year-old woman had a personal history of type 2 diabetes, hypercholesterolemia and mild hypertension, and a 6-month clinical history of angina and effort dyspnea, normal baseline ECG, and a clinically and electrically positive exercise stress test. She was considered high risk. Catheterization showed an ejection(More)