Juan-Manuel Alonso-Domínguez

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AIMS To analyse the differences in reticulocyte indices between delta beta thalassaemia trait (δβ-TT), beta thalassaemia trait (β-TT) and iron deficiency anaemia (IDA), and to correlate those differences with the physiopathological features of these three types of microcytoses. METHODS We performed a descriptive study of 428 samples (43 δβ-TT, 179 β-TT(More)
An 11-year-old boy was referred to our centre because of dementia, hypertrichosis and coarse facies. His facial features had begun to change at the age of 18 months and he had started to loose previously acquired skills with progressive loss of speech and walking ability. A peripheral blood film showed azurophilic inclusions in lymphocytes (left).(More)
BACKGROUND Haemoglobinopathies have spread owing to human migration, and the number of people needing diagnosis and management of these conditions is increasing. Clinicians need to accurately identify carriers and provide adequate genetic counselling in order to prevent the occurrence of homozygous or compound heterozygous offspring. OBJECTIVES To(More)
OBJECTIVES To analyze the differences not only in classic hematologic parameters but also in RBC subpopulations among δβ-thalassemia trait (δβ-TT), β-thalassemia trait (β-TT), and iron deficiency anemia (IDA) and to evaluate the role of fetal hemoglobin (HbF) in elevated RBC distribution width (RDW). METHODS Samples from 553 patients with microcytosis (74(More)
Most of α-thalassemia cases are caused by deletions of the structural α-globin genes. The 12 degree of microcytosis and hypochromia has been correlated with the number of affected α-globin 13 genes, suggesting a promising role of hematologic parameters as predictive diagnostic tools. 14 However, cut-off points for these parameters to discriminate between(More)
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