Juan Luis Fernández-Martínez

Learn More
BACKGROUND Fatigue is a common side effect of cancer (CA) treatment. We used a novel analytical method to identify and validate a specific gene cluster that is predictive of fatigue risk in prostate cancer patients (PCP) treated with radiotherapy (RT). METHODS A total of 44 PCP were categorized into high-fatigue (HF) and low-fatigue (LF) cohorts based on(More)
One of the major challenges in reservoir modeling for optimizing production is characterizing the spatial distribution of heterogeneous reservoir properties – facies, porosity, and permeability. Time-lapse seismic data in combination with geological and flow modeling has evolved as an important diagnostic tool for efficient reservoir characterization.(More)
There is growing evidence of an accumulation of mutations and mechanisms of resistance to targeted therapies in cancer. Non-small-cell lung cancer (NSCLC) is still an untreatable disease and is the leading cause of cancer related deaths worldwide (Gridelli et al., 2015). Various strategies have been proposed to increase the survival of NSCLC patients ,(More)
We have characterized a novel 21 amino acid-peptide derived from Antrum Mucosal Protein (AMP)-18 that mediates growth promotion of cultured normal epithelial cells and mitigates radiation-induced oral mucositis in animal models, while suppressing in vitro function of cancer cells. The objective of this study was to evaluate these dual potential therapeutic(More)
| Inverse problems are ill-posed. Posterior sampling is the way of providing an estimate of the uncertainty based on a finite set of the family of models that fit the observed data within the same tolerance. Monte Carlo methods are used for this purpose but they are highly inefficient. Global optimization methods are able to address the sampling problem.(More)
  • 1