Juan Lopez

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A link between Tau phosphorylation and aggregation has been shown in different models for Alzheimer disease, including yeast. We used human Tau purified from yeast models to generate new monoclonal antibodies, of which three were further characterized. The first antibody, ADx201, binds the Tau proline-rich region independently of the phosphorylation status,(More)
Ontologies define hierarchies of classes and attributes; they are meta-data: data about data. In the " traditional approach " to on-tology engineering, experts add new data by carefully analyzing others' ontologies and fitting their new concepts into the existing hierarchy. In the emerging " Semantic Web approach " , ordinary users may not look at anyone's(More)
Ontologies define hierarchies of classes and attributes; they are meta-data: data about data. XML Schema and RDF Schema are both (lightweight) ontology definition languages in that sense. In the " traditional " approach to ontology engineering, experts add new data by carefully analyzing others' ontologies and fitting their new concepts into the existing(More)
In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate(More)
Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare(More)
The marine sponge Ectyoplasia ferox produces antipredatory and allelopathic triterpenoid glycosides as part of its chemical defense repertoire against predators, competitors, and fouling organisms. These molecules are responsible for the pharmacological potential found in the glycosides present in this species. In order to observe the glycochemical(More)