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We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested against a nonredundant collection of 19,079 full-length cDNAs, 97.7% of the genes are aligned, without fragmentation, to the mapped super-scaffolds of one or the(More)
Recent research on universal and minimax wavelet shrinkage and thresholding methods has demonstrated near{ideal estimation performance in various asymptotic frameworks. However, image processing practice has shown that universal thresholding methods are outperformed by simple Bayesian estimators assuming independent wavelet coeecients and heavy{tailed(More)
Familial idiopathic basal ganglia calcification (IBGC) is a genetic condition with a wide spectrum of neuropsychiatric symptoms, including parkinsonism and dementia. Here, we identified mutations in SLC20A2, encoding the type III sodium-dependent phosphate transporter 2 (PiT2), in IBGC-affected families of varied ancestry, and we observed significantly(More)
BACKGROUND Early intensive insulin therapy in patients with newly diagnosed type 2 diabetes might improve beta-cell function and result in extended glycaemic remissions. We did a multicentre, randomised trial to compare the effects of transient intensive insulin therapy (continuous subcutaneous insulin infusion [CSII] or multiple daily insulin injections(More)
This paper presents a class of signal processing techniques for collaborative signal processing in ad hoc sensor networks, focusing on a vehicle tracking application. In particular, we study two types of commonly used sensors—acoustic-amplitude sensors for target distance estimation and direction-of-arrival sensors for bearing estimation—and investigate how(More)
Binding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and signal transduction. The fusion process has been well characterized, yet the role of coreceptor signaling remains elusive. Here, we describe a critical function of the chemokine coreceptor signaling in facilitating HIV infection of resting CD4 T cells. We find that static(More)
— This article describes information-based approaches to processing and organizing spatially distributed, multi-modal sensor data in a sensor network. Energy constrained networked sensing systems must rely on collabora-tive signal and information processing (CSIP) to dynamically allocate resources, maintain multiple sensing foci, and attend to new stimuli(More)
MOTIVATION It is well known that microRNAs (miRNAs) and genes work cooperatively to form the key part of gene regulatory networks. However, the specific functional roles of most miRNAs and their combinatorial effects in cellular processes are still unclear. The availability of multiple types of functional genomic data provides unprecedented opportunities to(More)
Location knowledge of nodes in a network is essential for many tasks such as routing, cooperative sensing, or service delivery in ad hoc, mobile, or sensor networks. This paper introduces a novel iterative method ILS for node localization starting with a relatively small number of anchor nodes in a large network. At each iteration, nodes are localized using(More)