Juan Li

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Fatty acid desaturation regulates membrane function and fat storage in animals. To determine the contribution of stearoyl-CoA desaturase (SCD) activity on fat storage and development in the nematode Caenorhabditis elegans, we analyzed the lipid composition and lipid droplet size in the fat-6;fat-7 desaturase mutants independently and in combination with(More)
OBJECTIVE To investigate potential functional variants in FTO and SH2B1 genes among Chinese children with obesity. METHODS Sanger sequencing of PCR products of all FTO and SH2B1 exons and their flanking regions were performed in 338 Chinese Han children with obesity and 221 age- and sex-matched lean controls. RESULTS A total of seven and five rare(More)
protein interaction between cPLA 2 and splice variants of ␣-subunit of BK channels.ing the splice variant composition of large-conductance Ca 2ϩ-activated potassium (BK) channels can alter their activity and apparent sensitivity to Ca 2ϩ and other regulators of activity. We hypothesized that differences in the responsiveness to arachidonic acid of GH3 and(More)
Given the sequence of transporters or channels of unknown secondary structure, it is usual to predict their putative transmembrane regions as alpha-helical. However, recent evidence for a facilitative glucose transporter (GLUT1) appears inconsistent with such predictions, which has led us to propose an alternative folding model for GLUTs based on the(More)
Previous investigations have shown that the binding of a selective hydrophilic positron emission tomography radiotracer for the dopamine transporter (DAT) (2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-18F-fluoroethyl)nortropane) decreased in monkey striatum during deep isoflurane anesthesia. Immunohistochemistry experiments suggested but did not prove(More)
Quercetin is one of the most abundant polyphenolic flavonoids found in fruits and vegetables and has anti-oxidative and anti-obesity effects. Because the small intestine is a major absorptive organ of dietary nutrients, it is likely that highly concentrated food constituents, including polyphenols, are present in the small intestinal epithelial cells,(More)
Directional liquid transportation is important for a variety of biological processes and technical applications. Although surface engineering through asymmetric chemical modification or geometrical patterning facilitates effective liquid manipulation and enables water droplet self-transportation on synthetic surfaces, self-transportation of oil droplets(More)
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