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A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis.
TLDR
A novel signaling circuit involving RIPK3 and PGE2 enhances accumulation and immunosuppressive activity of MDSCs, implicating its potential as a therapeutic target in anticancer immunotherapy and providing potential ideas for immunotherapy against colorectal cancer.
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RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis
TLDR
This work showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, is downregulated in hepatocellular carcinoma–associated macrophages, which correlated with tumorigenesis and enhanced the accumulation and polarization of M2 TAMs.
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Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database
TLDR
IORT was not inferior than EBRT considering the OS and CSS in the short-term follow-up of early breast cancer in select patients with favorable tumor size and receptor status, given the need for long-term monitoring of local control and radiation toxicity.
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Increased level of soluble syndecan-1 in serum correlates with myocardial expression in a rat model of myocardial infarction
TLDR
The expression of soluble Sdc1 in the sera of the rats in the MI group followed a similar pattern and was linearly correlated with the expression of SDC1 protein in theMI border zone, which may facilitate additional exploration of the utility of serum Sdc 1 as a biomarker for MI in humans.
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Sdc1 Overexpression Inhibits the p38 MAPK Pathway and Lessens Fibrotic Ventricular Remodeling in MI Rats
TLDR
Overexpression of Sdc1 can improve post-MI ventricular remodeling, and it is possible that the improvement is achieved through reducing apoptosis and suppressing inflammatory response and through the p38 MAPK signal transduction pathway.
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Changes in biological behaviors of rat dermal fibroblasts induced by high expression of MMP9.
TLDR
Fibroblasts with a high expression of M MP9 decreased proliferation, activity, secretion and migration of collagens, suggesting that MMP9 may inhibit the biological behaviors of fibroblast.
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Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment
TLDR
The results reveal the identities of anti-inflammatory versus pro-inflammatory metabolipidome and suggest the potential therapeutic mechanism of cupping treatment.
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Microbiota-derived SSL6 enhances the sensitivity of hepatocellular carcinoma to sorafenib by down-regulating glycolysis.
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Ventricular geometry–regularized QRSd predicts cardiac resynchronization therapy response: machine learning from crosstalk between electrocardiography and echocardiography
TLDR
A machine learning model with three classification algorithms with a triplet feature combination of QRSd/RWT, LBBB, and nonischemic cardiomyopathy repeatedly increased the classification rate more than 8% and could regularize ECG QRS duration (QRSd) and significantly enhance the correlation between Q RSd and CRT response.
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The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer
TLDR
The results reveal that SP1-12LOX axis signaling plays a key role in DDP-resistance and metastasis, which provide a new therapeutic target for ovarian cancer.
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