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A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis.
A novel signaling circuit involving RIPK3 and PGE2 enhances accumulation and immunosuppressive activity of MDSCs, implicating its potential as a therapeutic target in anticancer immunotherapy and providing potential ideas for immunotherapy against colorectal cancer.
RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis
This work showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, is downregulated in hepatocellular carcinoma–associated macrophages, which correlated with tumorigenesis and enhanced the accumulation and polarization of M2 TAMs.
Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database
- Juan Lei, Y. Wang, Z. Bi, Sheng-neng Xue, Bing Ou, Kan Liu
- MedicineJapanese Journal of Radiology
- 5 November 2019
IORT was not inferior than EBRT considering the OS and CSS in the short-term follow-up of early breast cancer in select patients with favorable tumor size and receptor status, given the need for long-term monitoring of local control and radiation toxicity.
Increased level of soluble syndecan-1 in serum correlates with myocardial expression in a rat model of myocardial infarction
The expression of soluble Sdc1 in the sera of the rats in the MI group followed a similar pattern and was linearly correlated with the expression of SDC1 protein in theMI border zone, which may facilitate additional exploration of the utility of serum Sdc 1 as a biomarker for MI in humans.
Sdc1 Overexpression Inhibits the p38 MAPK Pathway and Lessens Fibrotic Ventricular Remodeling in MI Rats
Overexpression of Sdc1 can improve post-MI ventricular remodeling, and it is possible that the improvement is achieved through reducing apoptosis and suppressing inflammatory response and through the p38 MAPK signal transduction pathway.
Changes in biological behaviors of rat dermal fibroblasts induced by high expression of MMP9.
- Sheng-neng Xue, Juan Lei, Diaozhu Lin, Chuan Yang, Li Yan
- Biology, MedicineWorld journal of emergency medicine
Fibroblasts with a high expression of M MP9 decreased proliferation, activity, secretion and migration of collagens, suggesting that MMP9 may inhibit the biological behaviors of fibroblast.
Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment
- Qi Zhang, Xiang Wang, Yongsheng Li
- Biology, MedicineCellular Physiology and Biochemistry
- 15 February 2018
The results reveal the identities of anti-inflammatory versus pro-inflammatory metabolipidome and suggest the potential therapeutic mechanism of cupping treatment.
Microbiota-derived SSL6 enhances the sensitivity of hepatocellular carcinoma to sorafenib by down-regulating glycolysis.
Ventricular geometry–regularized QRSd predicts cardiac resynchronization therapy response: machine learning from crosstalk between electrocardiography and echocardiography
A machine learning model with three classification algorithms with a triplet feature combination of QRSd/RWT, LBBB, and nonischemic cardiomyopathy repeatedly increased the classification rate more than 8% and could regularize ECG QRS duration (QRSd) and significantly enhance the correlation between Q RSd and CRT response.
The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer
The results reveal that SP1-12LOX axis signaling plays a key role in DDP-resistance and metastasis, which provide a new therapeutic target for ovarian cancer.