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BACKGROUND The biological mechanisms involved in inflammatory response to air pollution are not clearly understood. OBJECTIVE In this study we assessed the association of short-term air pollutant exposure with inflammatory markers and lung function. METHODS We studied a cohort of 158 asthmatic and 50 nonasthmatic school-age children, followed an average(More)
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within(More)
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with(More)
To evaluate whether acute effects of ozone, nitrogen dioxide, and particulates with mass median diameter less than 10 micro m could be attenuated by antioxidant vitamin supplementation, we conducted a randomized trial using a double-blinded design. Children with asthma (n = 158) who were residents of Mexico City were randomly given a daily supplement of(More)
Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in 492 Mexican children with asthma, predominantly atopic by skin prick test, and their parents using the Illumina HumanHap 550 K BeadChip to(More)
Motivated by the great asthma-prevalence variation throughout the world, we analyzed the rate variation of medical services due to asthma in the 32 Mexican states at the Instituto Mexicano del Seguro Social (approximately 24 million insured subjects). In 1993, a total of 406,036 services were due to asthma, and state rates ranged from 53 to 476 x 10,000(More)
BACKGROUND More than 200 asthma candidate genes have been examined in human association studies or identified with knockout mouse approaches. However, many have not been systematically replicated in human populations, especially those containing a large number of tagging single nucleotide polymorphisms (SNPs). OBJECTIVE We comprehensively evaluated the(More)
BACKGROUND A recent microarray study implicated arginase I (ARG1) and arginase II (ARG2) in mouse allergic asthma models and human asthma. OBJECTIVES To examine the association between genetic variation in ARG1 and ARG2 and childhood asthma and atopy risk. METHODS We enrolled 433 case-parent triads, consisting of patients with asthma 4 to 17 years old(More)
BACKGROUND S-nitrosothiols are potent endogenous bronchodilators depleted in asthmatic airway lining fluid. S-nitrosoglutathione reductase (GSNOR; also known as alcohol dehydrogenase 5 or formaldehyde dehydrogenase) catalyzes the metabolism of S-nitrosoglutathione (GSNO) and controls intracellular levels of S-nitrosothiols. GSNOR knockout mice have(More)
Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase (NQO1) and glutathione S-transferase (GST) M1 are phase II enzymes important in response to oxidative stress, such as occurs during exposure to ozone. We examined the relationship between functionally significant polymorphisms in NQO1 (Pro187Ser) and GSTM1 (homozygous deletion) and(More)