Six derivatives of the known biopesticide rotenone were prepared by several chemical transformations. Rotenone and its derivatives showed differential in vitro antiparasitic activity and selective cytotoxicity. In general, compounds were more active against Plasmodium falciparum than Leishmania panamensis. Rotenone had an EC50 of 19.0 µM against P.… (More)
The use of Information and Communication Technologies (ICTs) has gained an important role to enhance healthcare systems by increasing access to services, and improving the quality and equity of care. In order to evaluate the stage of ICTs adoption in the Uruguayan healthcare system, the Governmental Salud.uy Program carried out a national survey to… (More)
A novel compound involved in the aroma of the fruit Campomanesia lineatifolia was isolated; the structure was determined by spectroscopic methods, mainly 1D and 2D NMR.