Juan Francisco Infante-Bourzac

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BACKGROUND AND AIMS A live attenuated vaccine candidate against human cholera has been developed from the genetically modified Vibrio cholerae O1, biotype El Tor, serotype Ogawa, 638 strain. Previous single dose toxicity and local tolerance studies have demonstrated that the product is innocuous in Sprague Dawley rats by oral route and single dose. The(More)
BACKGROUND The AFCo1 cochleate is a potential novel adjuvant derived from Neisseria meningitidis B proteoliposome. AIM The aim was to assessing the safety of AFCo1 by single and repeated doses in Sprague Dawley rats. MATERIALS AND METHODS Rats were grouped for treatment with AFCo1, placebo formulation or control. The first study was a single intranasal(More)
Despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. The wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against Trichomonas vaginalis and other protozoa. Thus, the aim of(More)
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