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Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na(+) current (I(NaL)) is relevant and is currently under investigation. In this study we examined the role of I(NaL) in the electrophysiological phenotype of(More)
BACKGROUND Heart failure is a final common pathway or descriptor for various cardiac pathologies. It is associated with sudden cardiac death, which is frequently caused by ventricular arrhythmias. Electrophysiological remodeling, intercellular uncoupling, fibrosis and autonomic imbalance have been identified as major arrhythmogenic factors in heart failure(More)
Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or(More)
BACKGROUND AND OBJECTIVE Flow diverters are an exciting new class of endovascular devices that treat aneurysms by curative reconstruction of the parent artery. The Pipeline embolization device (PED) is the first FDA-approved intracranial flow diverting device available in the USA. This paper presents periprocedural results with the device in a series of 35(More)
The pipeline embolization device (PED) is a revolutionary tool for the endovascular treatment of intracranial aneurysms by flow diversion. Treatment using the PED often requires considerable manipulation and customization by the neurointerventionalist at the time of deployment. Proper use of the PED involves a novel set of techniques and associated jargon,(More)
BACKGROUND Heart failure is operationally defined as the inability of the heart to maintain blood flow to meet the needs of the body and it is the final common pathway of various cardiac pathologies. Electrophysiological remodeling, intercellular uncoupling and a pro-fibrotic response have been identified as major arrhythmogenic factors in heart failure. (More)
Failing hearts undergo electrical and structural remodeling, setting the stage for malignant arrhythmias. Increased dispersion of repolarization has been suggested to underlie increased arrhythmogenesis in human heart failure (HF). Recent experimental studies have shown that transmural dispersion of repolarization (TDR) decreases in failing hearts, while(More)
Failing hearts undergo electrical and structural remodeling, setting the stage for malignant arrhythmias. Specifically, failing hearts show enhanced late Na<sup>+</sup> current (I<sub>NaL</sub>) and cellular uncoupling. In the present study, the effects of these changes on transmural dispersion of repolarization (TDR), on action potential duration (APD)(More)