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EEG spectral analyses were conducted from 19 scalp locations for patients with mild (n=40), moderate (n=25), and severe (n=43) traumatic brain injury (TBI), 15 days to 4 years after injury. Severity of TBI was judged by emergency hospital admission records (Glasgow Coma Score and duration of coma and amnesia). Highest-loading EEG variables on each factor(More)
Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na(+) current (I(NaL)) is relevant and is currently under investigation. In this study we examined the role of I(NaL) in the electrophysiological phenotype of(More)
OBJECTIVES To study the relationship between magnetic resonance imaging (MRI) T(2) relaxation time and the power spectrum of the electroencephalogram (EEG) in long-term follow up of traumatic brain injury. METHODS Nineteen channel quantitative electroencephalograms or qEEG, tests of cognitive function and quantitative MRI T(2) relaxation times (qMRI) were(More)
BACKGROUND Heart failure is a final common pathway or descriptor for various cardiac pathologies. It is associated with sudden cardiac death, which is frequently caused by ventricular arrhythmias. Electrophysiological remodeling, intercellular uncoupling, fibrosis and autonomic imbalance have been identified as major arrhythmogenic factors in heart failure(More)
Analyzing the preferences of brain regions to oscillate at specific frequencies gives important functional information. Application of discrete inverse solutions for the EEG/MEG inverse problem in the frequency domain usually involves the use of many current sources (sometimes 10(4) or more) restricted to gray matter points, as the solution space for the(More)
BACKGROUND Heart failure is operationally defined as the inability of the heart to maintain blood flow to meet the needs of the body and it is the final common pathway of various cardiac pathologies. Electrophysiological remodeling, intercellular uncoupling and a pro-fibrotic response have been identified as major arrhythmogenic factors in heart failure. (More)
BACKGROUND AND PURPOSE Carotid cavernous fistulas (CCF) can be effectively treated by using different therapeutic alternatives such as detachable balloons and detachable coils, alone or in combination with N-butyl-2-cyanoacrylate (n-BCA) or Onyx. Stents have also been used in an attempt to improve preservation of the parent artery while still occluding the(More)
Failing hearts undergo electrical and structural remodeling, setting the stage for malignant arrhythmias. Increased dispersion of repolarization has been suggested to underlie increased arrhythmogenesis in human heart failure (HF). Recent experimental studies have shown that transmural dispersion of repolarization (TDR) decreases in failing hearts, while(More)
The pipeline embolization device (PED) is a revolutionary tool for the endovascular treatment of intracranial aneurysms by flow diversion. Treatment using the PED often requires considerable manipulation and customization by the neurointerventionalist at the time of deployment. Proper use of the PED involves a novel set of techniques and associated jargon,(More)
Failing hearts undergo electrical and structural remodeling, setting the stage for malignant arrhythmias. Specifically, failing hearts show enhanced late Na<sup>+</sup> current (I<sub>NaL</sub>) and cellular uncoupling. In the present study, the effects of these changes on transmural dispersion of repolarization (TDR), on action potential duration (APD)(More)