Juan Emilio Losa García

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The alveolar macrophage (AM) secretes interleukin 1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8), all of them inflammatory cytokines involved in the pathogenesis of many lung diseases. The aim of the present work was to evaluate the basal and stimulated secretion of these cytokines by human AMs.(More)
Diffuse pulmonary hemorrhage syndromes occasionally present diagnostic problems if the clinical picture is not very typical. The presence of hemosiderin-laden alveolar macrophages in bronchoalveolar lavage (BAL) fluid is a useful diagnostic criterion for this entity. However, in many diffuse interstitial pulmonary diseases (DIPD) there is a lesion at the(More)
Classically, cyclosporin A has been reported to exert its immunomodulatory action through its effect on T lymphocytes by inhibiting the synthesis of interleukin 2. However, the inhibition of T-lymphocyte activation does not suitably account for all the effects observed following cyclosporin A administration. It is possible that some of them could be due to(More)
BACKGROUND AND OBJECTIVE There is scant data comparing the incidence of pneumonia in the community and in the human immunodeficiency virus (HIV) population in highly active antiretroviral therapy (HAART) era. PATIENTS AND METHOD Prospective study during 18 months. Data were obtained by the means of the electronic clinical record. Incidence rate was(More)
Acute eosinophilic pneumonia is a recently described pulmonary phenomenon involving rapidly progressing respiratory insufficiency. Although it can appear at any age, it has never been reported during pregnancy and its impact on gestation is therefore unknown. We describe the clinical signs and course of disease in this first report of acute eosinophilic(More)
Diffuse alveolar-interstitial lung disease is a syndrome characterized, amongst others, by a common pathogenic scheme. The different phases of its pathogenesis are reviewed in this work. First of all, the concept of alveolitis is described, indicating its characteristics and general consequences of this lesion. Secondly, the different agents which could(More)
BACKGROUND AND OBJECTIVE Although risk factors for extended spectrum beta lactamase E. coli (EBLE) infection have been explored, specific risk factors for bacteremic urinary tract infection by EBLE have been hardly analyzed. PATIENTS AND METHODS We collected data from all patients with bacteremic urinary tract infection by E. coli attended in our hospital(More)