Juan Carlos Cruz

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BACKGROUND The long-term results of total hip arthroplasty performed with cement and use of a bulk autograft for acetabular reconstruction in patients with developmental dysplasia of the hip have varied considerably. We evaluated the results of total hip arthroplasties performed with acetabular bulk autograft to identify the factors that influence the(More)
Using a high throughput screen, we have identified a family of 12-residue long peptides that spontaneously translocate across membranes. These peptides function by a poorly understood mechanism that is very different from that of the well-known, highly cationic cell penetrating peptides such as the tat peptide from HIV. The newly discovered translocating(More)
Here we present a highly efficient protocol for on-the-resin coupling of fluorescent dyes or other functional groups to the N-termini of synthetic peptides prior to cleavage and deprotection. The protocol avoids expensive preactivated dyes and instead employs carboxylated dyes activated by large amounts of coupling reagents. The protocol was used to label(More)
An important family of existing coordination models and languages is based on the idea of trapping the messages exchanged by the coordinated entities and by the specification of rules governing the coordination. No model, including our CoLaS coordination model, justifies clearly the reason of their coordination rules. Why these rules and not others? Are(More)
To keep up with rapidly changing requirements applications are increasingly built out of software components. A new trend is now to give those software components control over their own actions, to turn them into concurrently running software agents. These software agents have to be relatively independent to keep them exchangeable. Although independent,(More)
Open Distributed Systems are the dominating intellectual issue of the end of this century. Figuring out how to build those systems will become a central issue in distributed system research in the next future. Although CORBA seems to provide all the necessary support to construct those systems. It provides a very limited support to the evolution of(More)
Most of the work on coordination technology so far has focused on the development of special coordination languages and environments that provide the basic mechanisms for realizing the coordination layer of an open system. It is clear that the idea of managing separately the coordination aspect from the computation in a language has a lot of advantages in(More)
We present gross and histologic evidence of coinfection in amphibians by fungal-like parasites of the order Dermocystidia (Amphibiocystidium sp.) and the fungus Batrachochytrium dendrobatidis. The condition was observed in frogs Hypsiboas pulchellus (Hylidae) from Uruguay in 2009 to 2012. This report is the first of dermocystids in Neotropical amphibians(More)