Juan Burgos

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PURPOSE To find any feature of prognostic significance among the clinical and histological characteristics of paediatric patients diagnosed with medulloblastoma (MB). MATERIALS AND METHODS Clinical charts and paraffin blocks of 79 paediatric patients from nine Spanish institutions diagnosed with MB between 1980 and 2001 were reviewed retrospectively.(More)
BACKGROUND This report describes a real-time PCR (Q-PCR) strategy to quantify Trypanosoma cruzi (T. cruzi) DNA in peripheral blood samples from Chagas disease patients targeted to conserved motifs within the repetitive satellite sequence. METHODOLOGY/PRINCIPAL FINDINGS The Q-PCR has a detection limit of 0.1 and 0.01 parasites/mL, with a dynamic range of(More)
— This paper describes a scalable method for paral-lelizing sampling-based motion planning algorithms. It subdivides configuration space (C-space) into (possibly overlapping) regions and independently, in parallel, uses standard (sequential) sampling-based planners to construct roadmaps in each region. Next, in parallel, regional roadmaps in adjacent(More)
— In this work, we describe an approach for model-ing and simulating group behaviors for pursuit-evasion that uses a graph-based representation of the environment and integrates multi-agent simulation with roadmap-based path planning. Our approach can be applied to more realistic scenarios than are typically studied in most previous work, including agents(More)
The extent of inflammation, fibrosis, and progression of chronic Chagas heart disease (cChHD) was associated with persistence of parasite DNA in cardiac lesions of necropsies or explants from Argentinean cChHD patients. A Trypanosoma cruzi-based polymerase chain reaction showed a positive result in 1) 15% of cardiac sections with less than 10 mononuclear(More)
We present an approach to the pursuit-evasion problem which is applicable to complex, multi-level environments. Studying each aspect of this problem in 3D structured environments is a distinct extension over many previous approaches. We also utilize our roadmap-based approach to multi-agent behavior when tracking agents of interest. Results are presented in(More)
We report a case of chagasic meningoencephalitis reactivation in a pregnant woman co-infected with Trypanosoma cruzi and HIV that was successfully managed with benznidazole and highly active antiretroviral therapy. Early diagnosis enabled rapid specific treatment that improved the health of the patient and her baby.
Trypanosoma cruzi the agent of Chagas disease is a monophyletic but heterogeneous group conformed by several Discrete Typing Units (DTUs) named TcI to TcVI characterized by genetic markers. The trans-sialidase (TS) is a virulence factor involved in cell invasion and pathogenesis that is differentially expressed in aggressive and less virulent parasite(More)
  • Samson Ade Jacobs, Nancy M Amato, Committee Members, Lawrence Rauchwerger, Valerie Taylor, Jim Morel +26 others
  • 2014
Motion planning is defined as the problem of finding a valid path taking a robot (or any movable object) from a given start configuration to a goal configuration in an environment. While motion planning has its roots in robotics, it now finds application in many other areas of scientic computing such as protein folding, drug design, virtual prototyping,(More)
Motion planning is the problem of computing valid paths through an environment. However, because computing exact solutions is intractable, sampling-based algorithms, such as Probabilistic RoadMaps (PRMs), have gained popularity. PRMs compute an approximate mapping of the planning space by sacrificing completeness in favor of efficiency. However, these(More)