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AIMS patients with diabetes mellitus (DM) have high platelet reactivity and are at increased risk of ischaemic events and bleeding post-acute coronary syndromes (ACS). In the PLATelet inhibition and patient Outcomes (PLATO) trial, ticagrelor reduced the primary composite endpoint of cardiovascular death, myocardial infarction, or stroke, but with similar(More)
BACKGROUND Patients with acute coronary syndromes and history of stroke or transient ischemic attack (TIA) have an increased rate of recurrent cardiac events and intracranial hemorrhages. METHODS AND RESULTS We evaluated treatment effects of ticagrelor versus clopidogrel in patients with acute coronary syndrome with and without a history of prior stroke(More)
AIMS The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safety of ticagrelor vs. clopidogrel in the non-ST-elevation acute coronary syndrome (NSTE-ACS) subgroup of the PLATO trial, in the total cohort, and in the subgroups managed with and without revascularization within(More)
We analyze a binary hypothesis testing problem built on a wireless sensor network (WSN) for detecting a stationary random process distributed both in space and time with a circularly-symmetric complex Gaussian distribution under the Neyman-Pearson (NP) framework. Using an analog scheme, the sensors transmit different linear combinations of their(More)
In this paper, we analyze a binary hypothesis testing problem using a wireless sensor network (WSN). Using Large Deviation Theory (LDT), we compute the exponents of the error probabilities for the detection of a constant under a correlated process. Each sensor transmits its local measurement through a multiple-access (MAC) Rician fading channel with a(More)
We analyze a binary hypothesis testing problem built on a wireless sensor network (WSN). Using Large Deviation Theory (LDT), we compute the probability error exponents of a distributed scheme for detecting a correlated circularly-symmetric complex Gaussian process under the Neyman-Pearson framework. Using an analog scheme, the sensors transmit scaled(More)
The objective was to compare the pharmacodynamic (PD) and pharmacokinetic (PK) effects of ticagrelor with clopidogrel among subjects of Hispanic ethnicity, as the PD and PK effects of antiplatelet agents among Hispanics are not specifically known. This was a randomised, open-label, crossover PD/PK study of 40 Hispanic subjects with stable coronary artery(More)
OBJECTIVE Ticagrelor is a direct-acting, reversibly-binding, oral P2Y12 receptor antagonist. It demonstrates predictable, linear pharmacokinetics. Two studies were undertaken to further elucidate the absolute bioavailability of ticagrelor and its regional absorption in the gastrointestinal (GI) tract. DESIGN AND METHODS In two open-label, randomized,(More)
—We consider the detection of a correlated random process immersed in noise in a wireless sensor network. Each node has an individual energy constraint and the communication with the processing central units are affected by the path loss propagation effect. Guided by energy efficiency concerns, we consider the partition of the whole network into clusters,(More)
—We analyze a binary hypothesis testing problem built on a wireless sensor network (WSN) for detecting a stationary random process distributed both in space and time with circularly-symmetric complex Gaussian distribution under the Neyman-Pearson framework. Using an analog scheme, the sensors transmit different linear combinations of their measurements(More)