Juan Antonio Martínez Navarro

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Oxidative stress has been reported to be a common underlying mechanism in the pathogenesis of many neurodegenerative disorders such as Alzheimer, Huntington, Creutzfeld-Jakob, and Parkinson disease. Despite the increasing number of articles showing a correlation between oxidative damage and neurodegeneration little is known about the genetic elements that(More)
Friedreich ataxia (FA), the most common form of hereditary ataxia, is caused by a deficit in the mitochondrial protein frataxin. While several hypotheses have been suggested, frataxin function is not well understood. Oxidative stress has been suggested to play a role in the pathophysiology of FA, but this view has been recently questioned, and its link to(More)
Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerative disorders such as Parkinson's(More)
Next generation collaborative systems will offer mobile users seamless and natural collaboration amongst a diversity of agents, within distributed, knowledge-rich and virtualized working environments. This ambitious goal faces numerous challenges from the underlying communication infrastructure to the high level application services, with the aim to provide(More)
BACKGROUND Friedreich's ataxia (FA), the most frequent form of inherited ataxias in the Caucasian population, is caused by a reduced expression of frataxin, a highly conserved protein. Model organisms have contributed greatly in the efforts to decipher the function of frataxin; however, the precise function of this protein remains elusive. Overexpression(More)
Drosophila melanogaster has contributed significantly to the understanding of disease mechanisms in Parkinson's disease (PD) as it is one of the very few PD model organisms that allow the study of age-dependent behavioral defects, physiology and histology, and genetic interactions among different PD-related genes. However, there have been contradictory(More)
cells and muscles as tools to study neurodegenerative diseases in Drosophila melanogater " Summary: Drosophila melanogaster has contributed significantly to the understanding of disease mechanisms in Friedreich's ataxia (FRDA) and Parkinson's disease (PD) as it is one of the very few model organisms that allow the study genetic interactions among(More)
Development of distributed systems is a difficult task. Declarative programming techniques hold a promising potential for effectively supporting programmer in this challenge. While Datalog-based languages have been actively explored for programming distributed systems, Prolog received relatively little attention in this application area so far. In this(More)
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