Juan Alfonso Lara

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Traditional microdialysis techniques provide qualitative data, although quantitative data are often required for pharmacodynamic analyses. This study evaluated a potentially useful in vivo delivery technique to calibrate microdialysis probes for ethanol. We measured in vivo delivery extraction fractions within subjects across 2 days and found no change over(More)
The comparison of two time series and the extraction of subsequences that are common to the two is a complex data mining problem. Many existing techniques, like the Discrete Fourier Transform (DFT), offer solutions for comparing two whole time series. Often, however, the important thing is to analyse certain regions, known as events, rather than the whole(More)
The electroencephalograph (EEG) signal is one of the most widely used signals in the biomedicine field due to its rich information about human tasks. This research study describes a new approach based on i) build reference models from a set of time series, based on the analysis of the events that they contain, is suitable for domains where the relevant(More)
OBJECTIVES We present a framework specially designed to deal with structurally complex data, where all individuals have the same structure, as is the case in many medical domains. A structurally complex individual may be composed of any type of single-valued or multivalued attributes, including time series, for example. These attributes are structured(More)
There are now a great many domains where information is recorded by sensors over a limited time period or on a permanent basis. This data flow leads to sequences of data known as time series. In many domains, like seismography or medicine, time series analysis focuses on particular regions of interest, known as events, whereas the remainder of the time(More)
Creating a reference model that represents a given set of time series is a relevant problem as it can be applied to a wide range of tasks like diagnosis, decision support, fraud detection, etc. In some domains, like seismography or medicine, the relevant information contained in the time series is concentrated in short periods of time called events. In this(More)