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IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways
- Sue-Yun Hwang, Ju-Young Kim, +4 authors Ho‐Youn Kim
- Biology, Medicine
- Arthritis research & therapy
- 21 January 2004
IL-17 appears to be a stronger inducer of IL-6 and IL-8 than IL-15, and even exerted activation comparable to that ofIL-1β in RA FLS, and provide grounds for targeting IL-17-associated pathways in therapeutic modulation of arthritis inflammation. Expand
Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes.
It is found that human resistin directly binds to CAP1 in monocytes and upregulates cyclic AMP concentration, protein kinase A activity, and NF-κB-related transcription of inflammatory cytokines to modulate inflammatory action of monocytes. Expand
Tensile and compressive behavior of tungsten, molybdenum, tantalum and niobium at the nanoscale
In situ nanomechanical tests are carried out to investigate the tensile and compressive behavior of -oriented body-centered cubic (bcc) metals W, Mo, Ta and Nb with nanometer dimensions. We find that… Expand
Identification of a Novel Role of T Cells in Postnatal Vasculogenesis: Characterization of Endothelial Progenitor Cell Colonies
Findings suggest that angiogenic T cells could be a potential therapeutic target for ischemic cardiovascular diseases. Expand
Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis.
This study reports that neuronal activity decreases the expression of secreted frizzled-related protein 3 (sFRP3), a naturally secreted Wnt inhibitor highly expressed by adult dentate gyrus granule neurons, and suggests an interesting activity-dependent mechanism governing adult neurogenesis via the acute release of tonic inhibition. Expand
Differential Cardiovascular Outcomes after Dipeptidyl Peptidase-4 Inhibitor, Sulfonylurea, and Pioglitazone Therapy, All in Combination with Metformin, for Type 2 Diabetes: A Population-Based Cohort…
Compared with a DPP-4 inhibitor plus metformin, treatment with a sulfonylurea drug plus meetformin was associated with increased risks of total CVD, MI, and IS, whereas the use of pioglitazone plus met formin wasassociated with decreased total CVC and IS risks. Expand
Statistics of dislocation slip avalanches in nanosized single crystals show tuned critical behavior predicted by a simple mean field model.
- N. Friedman, A. Jennings, +5 authors K. Dahmen
- Materials Science, Medicine
- Physical review letters
- 30 August 2012
It is shown for the first time that plasticity reflects tuned criticality, by collapsing the stress-dependent slip-size distributions onto a predicted scaling function, and both power-law exponents and scaling function agree with mean-field theory predictions. Expand
Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes.
It is suggested that exendin-4 might increase BMD by decreasing the expression of SOST/sclerostin in osteocytes in type 2 diabetes. Expand
Engineered polymeric nanoparticles for soil remediation.
- Warapong Tungittiplakorn, L. W. Lion, C. Cohen, Ju-Young Kim
- Chemistry, Medicine
- Environmental science & technology
- 28 January 2004
It is shown that APU particles can be engineered to achieve desired properties and can be designed to have hydrophobic interior regions that confer a high affinity for phenanthrene (PHEN) and hydrophilic surfaces that promote particle mobility in soil. Expand
Parenteral 17beta-estradiol decreases fasting blood glucose levels in non-obese mice with short-term ovariectomy.
Short-term parenteral 17beta-estradiol treatment decreases the fasting blood glucose levels not via insulin sensitivity of the skeletal muscle in non-obese mice with short-term ovariectomy, and does not affect insulin sensitivity and the components of the insulin signaling pathway in the liver and skeletal muscle. Expand