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A polyubiquitin comprises multiple covalently linked ubiquitins and recognizes myriad targets. Free or bound to ligands, polyubiquitins are found in different arrangements of ubiquitin subunits. To understand the structural basis for polyubiquitin quaternary plasticity and to explore the target recognition mechanism, we characterize the conformational space(More)
PURPOSE Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis. We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated with overall survival (OS) and distant metastasis-free survival (DMFS) in patients with non-small cell lung cancer (NSCLC) treated with definitive radiotherapy, with or without(More)
OBJECTIVE To investigate the association between fasting plasma glucose level and pulmonary function. RESEARCH DESIGN AND METHODS Nutritional information, pulmonary function data, and laboratory test data from 9,223 subjects from the fourth Korea National Health and Nutrition Examination Survey were examined. The participants were divided into five groups(More)
BACKGROUND MUC5B is glycoprotein secreted by bronchial glands. A promoter variant in MUC5B, rs35705950, was previously found to be strongly associated with the incidence of idiopathic pulmonary fibrosis (IPF) and also the overall survival (OS) of such patients. Patients with IPF and patients with radiation pneumonitis (RP) have the similar pathologic(More)
Specific cell surface labeling is essential for visualizing the internalization processes of G-protein coupled receptors (GPCRs) and for gaining mechanistic insight of GPCR functions. Here we present a rapid, specific, and versatile labeling scheme for GPCRs at living-cell membrane with the use of a split green fluorescent protein (GFP). Demonstrated with(More)
Although the e-commerce of agro-food in mainland China started much later than that in America and European Union, the speed and potential of its growing shouldn't be underestimated. In recent years, increasing cyber citizens emerged in mainland China, who'd created huge needs for online transaction for all kinds of commodities ranging from daily(More)
We previously showed that human papillomavirus (HPV) serostatus was not an independent risk factor for esophageal squamous cell carcinoma(ESCC) in nonsmokers and nondrinkers; however, HPV increased the risk in smokers. Here we investigated possible interactions between HPV16 serostatus and three susceptibility loci identified in GWASs at apoptosis(More)
As one of the bulk crops ranking only after the three trades in China, cotton is of great strategic importance, and the cotton textile industry is the pillar industry of China's foreign trade. This paper studies the cotton futures price index and the spot price of cotton in Zhengzhou Commodity Exchange from June 2004 to September 2010 as samples. By using(More)
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