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Nucleation and kinetics of defects at the atomic scale provide the most fundamental information about the mechanical response of materials and surfaces. Recent advances in experimental and computational analyses allow us to study this phenomenon in the context of nanoindentation and localized mechanical probing of surfaces. Here, we present an analytical(More)
Nanometre-scale contact experiments and simulations demonstrate the potential to probe incipient plasticity--the onset of permanent deformation--in crystals. Such studies also point to the need for an understanding of the mechanisms governing defect nucleation in a broad range of fields and applications. Here we present a fundamental framework for(More)
Recent advances in nanotechnology have stimulated novel applications in biomedicine where nanoparticles (NPs) are used to achieve drug delivery and photodynamic therapy. In chemotherapeutic cancer treatment, tumor-specific drug delivery is a topic of considerable research interest for achieving enhanced therapeutic efficacy and for mitigating adverse side(More)
We report the creation of a nanoscale electrochemical device inside a transmission electron microscope--consisting of a single tin dioxide (SnO(2)) nanowire anode, an ionic liquid electrolyte, and a bulk lithium cobalt dioxide (LiCoO(2)) cathode--and the in situ observation of the lithiation of the SnO(2) nanowire during electrochemical charging. Upon(More)
Dental caries and periodontal disease are widespread diseases for which microorganism infections have been identified as the main etiology. Silver nanoparticles (Ag Nps) were considered as potential control oral bacteria infection agent due to its excellent antimicrobial activity and non acute toxic effects on human cells. In this work, stable Ag Nps with(More)
Dislocation nucleation is essential to the plastic deformation of small-volume crystalline solids. The free surface may act as an effective source of dislocations to initiate and sustain plastic flow, in conjunction with bulk sources. Here, we develop an atomistic modeling framework to address the probabilistic nature of surface dislocation nucleation. We(More)
Nano-twinned copper exhibits an unusual combination of ultrahigh strength and high ductility, along with increased strain-rate sensitivity. We develop a mechanistic framework for predicting the rate sensitivity and elucidating the origin of ductility in terms of the interactions of dislocations with interfaces. Using atomistic reaction pathway calculations,(More)
During its asexual development within the red blood cell (RBC), Plasmodium falciparum (Pf), the most virulent human malaria parasite, exports proteins that modify the host RBC membrane. The attendant increase in cell stiffness and cytoadherence leads to sequestration of infected RBCs in microvasculature, which enables the parasite to evade the spleen, and(More)
Recent developments in multiscale computation allow the solution of coarse equations for the expected macroscopic behavior of microscopically evolving particles without ever obtaining these coarse equations in closed form. The closure is obtained on demand through appropriately initialized bursts of microscopic simulation. The effective coupling of(More)