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RNF43, an E3 ligase, inhibits Wnt signaling by removing Wnt receptors and behaves as a candidate tumor suppressor. Recent studies identified that RNF43 gene was frequently mutated in gastric (GC), colorectal (CRC), and endometrial cancers with high microsatellite instability (MSI-H). The aim of this study is to explore whether RNF43 gene is mutated in GC(More)
The most effective method to reduce CO 2 gas emission from the steam power plant is to improve its performance by elevating the steam temperature to more than 700 • C. For this, it is necessary to develop applicable materials at high temperatures. Ni-based Alloy 617 and 12Cr steel are used in steam power plants, due to their remarkable mechanical(More)
The present study investigated the role of the peripheral NR2 subunits of N-methyl-d-aspartatic acid (NMDA) receptors in inflammatory orofacial pain. Experiments were carried out using adult male Sprague-Dawley rats weighing 220 to 280 g. Formalin (5%, 50 μl) was applied subcutaneously to the vibrissa pad. For each animal, the number of noxious behavioral(More)
To the Editor Werner syndrome, an autosomal recessive disorder causing premature aging, is caused by truncating mutations in Werner syndrome gene (WRN) that encodes a DNA helicase with exonuclease activity [1]. Patients with Werner syndrome have an increased cancer incidence as well, suggesting that the lack normal WRN function affects tumorigenesis [2].(More)
A transcription factor-encoding gene ZNF292 is considered a candidate tumor suppressor gene (TSG). Its mutations have been identified in cancers from liver, colon, and bone marrow. However, ZNF292 inactivating mutations that might suppress the TSG functions have not been reported in gastric (GC) and colorectal cancers (CRC) with microsatellite instability(More)
To the Editor: KNSTRN gene encodes the kinetochore-localized astrin/ spag5-binding protein that modulates chromosome segregation during mitosis [1]. A recent genomic study identified recurrent somatic mutations of the KNSTRN in 19 % of cutaneous squamous cell carcinoma (SCC) [2]. Of the mutations detected, more than half of them were recurrent at a specific(More)
WISP3 is involved in many cancer-related processes including epithelial-mesenchymal transition, cell death, invasion, and metastasis and is considered a tumor suppressor. The aim of our study was to find whether WISP3 gene was mutated and expressionally altered in gastric (GC) and colorectal cancers (CRCs). WISP3 gene possesses a mononucleotide repeat in(More)
Loss of ZMPSTE24 is related to progeroid phenotypes in human. Cells in zmpste24-deficient mice show delayed DNA damage response, increased aneuploidy and increased genomic instability, which are considered features of cancer cells. The aim of this study was to address whether ZMPSTE24 gene was mutated in colorectal cancers (CRCs) and gastric (GCs), and its(More)
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