Ju Hwa Lee

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To the Editor Werner syndrome, an autosomal recessive disorder causing premature aging, is caused by truncating mutations in Werner syndrome gene (WRN) that encodes a DNA helicase with exonuclease activity [1]. Patients with Werner syndrome have an increased cancer incidence as well, suggesting that the lack normal WRN function affects tumorigenesis [2].(More)
To the Editor: KNSTRN gene encodes the kinetochore-localized astrin/ spag5-binding protein that modulates chromosome segregation during mitosis [1]. A recent genomic study identified recurrent somatic mutations of the KNSTRN in 19 % of cutaneous squamous cell carcinoma (SCC) [2]. Of the mutations detected, more than half of them were recurrent at a specific(More)
The present study investigated the role of the peripheral NR2 subunits of N-methyl-d-aspartatic acid (NMDA) receptors in inflammatory orofacial pain. Experiments were carried out using adult male Sprague-Dawley rats weighing 220 to 280 g. Formalin (5%, 50 μl) was applied subcutaneously to the vibrissa pad. For each animal, the number of noxious behavioral(More)
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