Jozarni J Dlabac-de Lange

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From a prospectively defined cohort of patients who underwent either general, regional or combined anaesthesia from 1 January 1995 to 1 January 1997 (n = 869 483), all consecutive patients (n = 811) who died within 24 h or remained unintentionally comatose 24 h after anaesthesia were classified to determine a relationship with anaesthesia. These deaths (n =(More)
BACKGROUND Few studies have investigated the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment for negative symptoms of schizophrenia, reporting inconsistent results. We aimed to investigate whether 10 Hz stimulation of the bilateral dorsolateral prefrontal cortex during 3 weeks enhances treatment effects. METHOD A multicenter(More)
BACKGROUND Prefrontal cortical dysfunction is frequently reported in schizophrenia and is thought to underlie negative symptoms of schizophrenia. Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate neuronal activity and has been shown to improve negative symptoms in patients with schizophrenia, but the underlying neural mechanism is unknown. (More)
BACKGROUND Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for the negative symptoms of schizophrenia. During the past decade, several trials have reported on the efficacy of rTMS treatment; however, the results were inconsistent. OBJECTIVE To assess the efficacy of prefrontal rTMS for treating negative symptoms of(More)
Median nerve somatosensory evoked potentials (SSEP) were studied in 10 ASA I patients during general anaesthesia with propofol, vecuronium and fentanyl after premedication with diazepam. N14 and N20 latencies, central conduction time (CCT) and corresponding interpeak amplitudes were assessed at induction, after intubation, during steady state, at(More)
BACKGROUND We previously demonstrated the involvement of the Ca2+-independent protein kinase C-delta (PKC-delta) isoform in sevoflurane-induced cardioprotection against ischaemia and reperfusion (I/R) injury. Since sevoflurane is known to modulate myocardial Ca2+-handling directly, in this study we investigated the role of the Ca2+-dependent PKC-alpha(More)
H-Magnetic Resonance Spectroscopy ((1)H-MRS) can offer insights in various neuropathologies by measuring metabolite levels in the brain. In the current study we investigated the levels of glutamate + glutamine (Glx, neurotransmitter and precursor) and N-Acetyl Aspartate + glutamic acid (NAA + NAAG; neuronal viability) in the prefrontal cortex of patients(More)
The pathways of nociception, concerning dentogenic pain, are followed from the peripheral nociceptors to the cortex. The branches of the trigeminal nerve supply the semilunar ganglion. From this ganglion the trigeminal nuclei are reached, extending from the bottom of the third ventricle to the upper cervical segments. The thalamus and subsequently the(More)
This article describes the occurrence of an epileptic insult immediately after the intravenous bolus administration of 200 mg propofol (Diprivan) in a healthy patient with no medical history of epilepsy or other neurological diseases. Extensive neurological examinations including EEG and CT scan did not reveal any abnormalities. We want to emphasise that(More)