Joyce M Slingerland

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

Isabel M. Chu, Ludger Hengst, Joyce M Slingerland
Nature Reviews Cancer
2008

The cyclin-dependent kinase (Cdk) inhibitor p27 (also known as KIP1) regulates cell proliferation, cell motility and apoptosis. Interestingly, the protein can exert both positive and negative… (More)

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

Jiyong Liang, Judit Zubovitz, +9 authors Joyce M Slingerland
Nature Medicine
2002

Mechanisms linking mitogenic and growth inhibitory cytokine signaling and the cell cycle have not been fully elucidated in either cancer or in normal cells. Here we show that activation of protein… (More)

Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.

As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing cancer therapeutic target. Recent studies have investigated the mechanisms underlying the tumor-promoting… (More)

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Jiyong Liang, Shan H. Shao, +9 authors Gordon B. Mills
Nature Cell Biology
2007

Nutrients and bioenergetics are prerequisites for proliferation and survival of mammalian cells. We present evidence that the cyclin-dependent kinase inhibitor p27Kip1, is phosphorylated at Thr 198… (More)

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy.

Seth A. Wander, Bryan T. J. Hennessy, Joyce M Slingerland
The Journal of clinical investigation
2011

Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly… (More)

New functional activities for the p21 family of CDK inhibitors.

Joshua LaBaer, Matthew Garrett, +5 authors Ed Harlow
Genes & development
1997

The association of cdk4 with D-type cyclins to form functional kinase complexes is comparatively inefficient. This has led to the suggestion that assembly might be a regulated step. In this report we… (More)

mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation.

Feng Hong, Michelle D. Larrea, Cheryl A Doughty, David Joseph Kwiatkowski, Rachel M. Squillace, Joyce M Slingerland
Molecular cell
2008

The cell-cycle effects of mTORC1 are not fully understood. We provide evidence that mTOR-raptor phosphorylates SGK1 to modulate p27 function. Cellular mTOR activation, by refeeding of amino… (More)

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

Charles Catzavelos, Nandita Bhattacharya, +10 authors Joyce M Slingerland
Nature Medicine
1997

Breast cancer is the second leading cause of cancer death in North American women. There is considerable need for reliable prognostic markers to assist clinicians in making management decisions.… (More)

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1

Brad St. Croix, Capucine Sheehan, Janusz W. Rak, Viví Ann Flørenes, Joyce M Slingerland, Robert S. Kerbel
The Journal of cell biology
1998

Recent studies have demonstrated the importance of E-cadherin, a homophilic cell-cell adhesion molecule, in contact inhibition of growth of normal epithelial cells. Many tumor cells also maintain… (More)

p27 Phosphorylation by Src Regulates Inhibition of Cyclin E-Cdk2

Isabel M. Chu, Jun Sun, +7 authors Joyce M Slingerland
Cell
2007

The kinase inhibitor p27Kip1 regulates the G1 cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74… (More)

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