Joyce E Nicklaus

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The objective was to examine functional connectivity linked to the auditory system in patients with bothersome tinnitus. Activity was low frequency (< 0.1 Hz), spontaneous blood oxygenation level-dependent (BOLD) responses at rest. The question was whether the experience of chronic bothersome tinnitus induced changes in synaptic efficacy between(More)
OBJECTIVE To explore the feasibility of ecological momentary assessments (EMAs) as a tool to more accurately assess the level of bother from tinnitus. STUDY DESIGN Longitudinal observational study. SETTING Washington University Department of Otolaryngology-Head and Neck Surgery faculty practice plan. SUBJECTS AND METHODS Twenty participants with(More)
OBJECTIVE To examine the effectiveness and safety of low-frequency repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal junction in a cohort of patients with bothersome tinnitus. DESIGN Crossover, double-blind, randomized clinical trial. SETTING Outpatient academic medical center. PARTICIPANTS Fourteen adults aged 42 to 59 years(More)
IMPORTANCE This research examines the impact of 4 weeks of repetitive transcranial magnetic stimulation (rTMS) stimulation to the temporoparietal junction and compares the results of this longer duration of treatment with a similar stimulus protocol of only 2 weeks' duration. OBJECTIVE To examine the effectiveness and safety of 4 weeks of low-frequency(More)
Neurocognitive tests compared abilities in people with bothersome tinnitus against an age-, gender-, and education-matched normative population. Participants between 18 and 60 years had subjective, unilateral or bilateral, nonpulsatile tinnitus for >6 months and a Tinnitus Handicap Inventory score of ≥ 38. Results from a first testing session showed(More)
IMPORTANCE Tinnitus affects more than 40 million people in the Unites States, and cognitive difficulties are among the most commonly associated symptoms. OBJECTIVE To test the feasibility and preliminarily the effectiveness of using a putative neuroplasticity-enhancing drug, D-cycloserine, to facilitate a computer-assisted CT program for improving(More)
OBJECTIVE To evaluate the impact of a Mindfulness Based Stress Reduction (MBSR) program in patients with chronic bothersome tinnitus on the (1) severity of symptoms of tinnitus and (2) functional connectivity in neural attention networks. STUDY DESIGN Open-label interventional pilot study. SETTING Outpatient academic medical center. SUBJECTS A total(More)
OBJECTIVE To determine changes in cortical neural networks as defined by resting-state functional connectivity magnetic resonance imaging during voluntary modulation of tinnitus with orofacial maneuvers. STUDY DESIGN Cross-sectional study. SETTING Academic medical center. SUBJECTS AND METHODS Participants were scanned during the maneuver and also at(More)
OBJECTIVES A common complaint of cancer patients is the experience of cognitive difficulty during and after chemotherapy. We hypothesized that cognitive impairment may result from dysfunction in large-scale brain networks, particularly those involved in attentional control. METHODS Using a case-control design, this study includes women with a history of(More)
Importance Individuals with tinnitus have poorer working memory, slower processing speeds and reaction times, and deficiencies in selective attention, all of which interfere with readiness and performance. Brain Fitness Program-Tinnitus (BFP-T) is a cognitive training program specially designed to exploit neuroplasticity for preservation and expansion of(More)