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Aberrant activation of Hedgehog (Hh) signaling is causative of BCCs and has been associated with a fraction of SCCs. Desmoglein 2 (Dsg2) is an adhesion protein that is upregulated in many cancers and overexpression of Dsg2 in the epidermis renders mice more susceptible to squamous-derived neoplasia. Here we examined a potential crosstalk between Dsg2 and Hh(More)
L eukemia cutis (LC) is a rare, cutaneous infiltration of neoplastic leukemic cells and correlates strongly to additional sites of extra-medullary disease. 1 LC is a nonspecific term for the cutaneous manifestations of many subtypes of leukemia; therefore, the cutaneous morphology and histopathology of LC varies widely. This distinction makes it clinically(More)
Acquired brachial cutaneous dyschromatosis is an acquired pigmentary disorder that has been described in only 20 patients but likely affects many more. This case of a man with acquired brachial cutaneous dyschromatosis is unique as most reports are in women. We report the case of a 60-year-old male who presents with an asymptomatic eruption characterized by(More)
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