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The only way we can interact with the world is through movement, and our hands are our primary mode of interaction with objects and other individuals. Understanding the neural computations underlying hand motor control in real-life situations are critical, both for the development of dexterous neuroprosthetic hands, as well as studying a defining element of(More)
Neuronal avalanches are spontaneous activity cascades observed in superficial cortical layers with statistical properties expected from the network operating near a critical point [1]. In such a network, neuronal activity on one active site triggers, on average, similar activity at other site and therefore the overall activity does not increase or die out(More)
We simultaneously recorded local field potentials (LFPs) in the primary motor cortex and sensorimotor striatum in awake, freely behaving, 6-OHDA lesioned hemi-parkinsonian rats in order to study the features directly related to pathological states such as parkinsonian state and levodopa-induced dyskinesia. We analyzed the spectral characteristics of the(More)
16 The only way we can interact with the world is through movements, and our primary interactions are 17 via the hands, thus any loss of hand function has immediate impact on our quality of life. However, 18 to date it has not been systematically assessed how coordination in the hand's joints affects every day 19 actions. This is important for two(More)
Network oscillations are ubiquitous across many brain regions. In the basal ganglia, oscillations are also present at many levels and a wide range of characteristic frequencies have been reported to occur during both health and disease. The striatum, the main input nucleus of the basal ganglia, receives massive glutamatergic inputs from the cortex and is(More)
The Basal Ganglia represent subcortical structures that have a crucial role in determining when a given motor program should be selected and called into action [1]. The input region of the Basal Ganglia (the striatum) contains several distinct cell types. 90-95% of them are medium spiny projection neurons (MSNs) that have high threshold for activation and(More)
18 We simultaneously recorded local field potentials in the primary motor cortex and sensorimotor 19 striatum in awake, freely behaving, 6-OHDA lesioned hemi-parkinsonian rats in order to study the 20 features directly related to pathological states such as parkinsonian state and levodopa-induced 21 dyskinesia. We analysed the spectral characteristics of(More)
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