Jouko Yliruusi

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Powder flow is influenced by environmental factors, such as moisture and static electricity, as well as powder related factors, such as morphology, size, size distribution, density, and surface area. Pharmaceutical solids may be exposed to water during storage in an atmosphere containing water vapor, or in a dosage form consisting of materials (e.g.,(More)
A system for fluidized bed granulator automation with in-line multichannel near infrared (NIR) moisture measurement and a unique air flow rate measurement design was assembled, and the information gained was investigated. The multivariate process data collected was analyzed using principal component analysis (PCA). The test materials (theophylline and(More)
This study assesses the fluidized bed granulation process for the optimization of a model formulation using in-line near-infrared (NIR) spectroscopy for moisture determination. The granulation process was analyzed using an automated granulator and optimization of the verapamil hydrochloride formulation was performed using a mixture design. The NIR setup(More)
Magnesium stearate (MS) is the most commonly used lubricant in pharmaceutical industry. During blending, MS particles form a thin layer on the surfaces of the excipient and drug particles prohibiting the bonding from forming between the particles. This hydrophobic layer decreases the tensile strength of tablets and prevents water from penetrating into the(More)
  • Paulus Seitavuopio, Jouko Yliruusi, Jukka Docent, Rantanen, Docent Jukka-Pekka, Mannermaa Verman +5 others
  • 2006
Seitavuopio, P.J, 2006. The roughness and imaging characterisation of different pharmaceutical surfaces Dissertationes biocientiarum molecularium Universitatis Helsingiensis in Viikki, 10/2006, The surface properties of solid state pharmaceutics are of critical importance. Processing modifies the surfaces and effects surface roughness, which influences the(More)
The swelling behavior of novel Dome Matrix drug delivery modules was investigated using high-resolution X-ray computed tomography studies. The technique was exploited to investigate the swelling front position and the conditions of the interacting surfaces in situ without removing the sample from the medium during swelling. Surface and volume evolution of(More)
A biologically inspired spiking neural network model, the pulse coupled neural network (PCNN), has been applied for the first time in bulk particle characterization, and specifically in the characterization of pharmaceutical granule size distributions. The PCNN was trained on surface images of pharmaceutical granule beds, and the adjustable parameters(More)
Airaksinen, S.T.T., 2005. Role of excipients in moisture sorption and physical stability of solid pharmaceutical formulations. The interaction of moisture with pharmaceutical solids is crucial to an understanding of water-based processes, e.g. manufacturing processes or prediction of solid dosage form stability and shelf life. Sorbed moisture of either the(More)
In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied. Pure sodium halides (NaF, NaBr, NaCl, and NaI) were chosen as model substances because of their simple and similar structure. Based on the data available in the literature and our own measurements,(More)