Jouko O. Isolauri

Learn More
Symptoms suggestive of gastro-oesophageal reflux disease are very common. The aim of the study was to assess the prevalence of these symptoms and factors influencing them in an unselected adult population. A questionnaire was mailed to a random sample of 2500 people aged > or = 20 years. The questions concerned heartburn, regurgitation, dysphagia, chest and(More)
Of 46 patients who had Nissen fundoplication for proved gastro-oesophageal reflux, 25 were available for follow up after a median of 20 years, 15 had died of unrelated causes, and six could not be traced. All 25 patients in the follow up study were personally interviewed: 21 consented to an endoscopy, 14 to 24 hour recording of oesophageal pH and manometry,(More)
The stomach is the organ most used for restoring esophageal continuity after esophageal resection for malignancy. In the present series, we report our experience over a 20-year period (1965 through 1984) with an alternative method, colon interposition. Two hundred forty-eight patients (124 men and 124 women) underwent colon interposition. Seventy-one(More)
Fifty patients reoperated for failed Nissen fundoplication are presented; 29 patients (group 2) were operated between 1983 and 1988 while 21 patients (group 1) were operated before 1983. In group 1, the “slipped Nissen” had been the most frequent cause of reoperation (48%). In group 2, the most frequent causes for the unsuccessful operation were: (1)(More)
BACKGROUND It has been suggested that fundic mobilization in Nissen fundoplication decreases adverse postoperative symptoms and increases the durability of the fundic wrap. There are no previous randomized, prospection long-term studies assessing this. This study addresses the question. METHODS Fifty consecutive patients were randomized to undergo open(More)
BACKGROUND Tuberculous involvement of the esophagus has been extremely rare during the past 40 years. It will be, however, more frequently encountered in the future, as the number of immunocompromised patients is growing. This condition is usually secondary to infection in other thoracic sites, such as lungs, larynx, or mediastinum. The diagnosis is(More)
OBJECTIVE To evaluate the influence of antireflux surgery on gastric emptying. DESIGN Nonrandomized controlled trial 3 months before and after surgical intervention. SETTING Secondary and tertiary referral center. PATIENTS AND CONTROL SUBJECTS Twenty consecutive patients (7 women, 13 men), mean age 49.2 years, with symptomatic, objectively confirmed(More)
BACKGROUND An increase in postoperative dysphagia has been reported after laparoscopic fundoplication. Our aim was to compare laparoscopic Nissen-Rossetti fundoplication to open fundoplication regarding oesophageal clearance and dysphagia in a prospective, randomized study. METHODS Twenty-eight consecutive patients with objectively observed(More)
OBJECTIVE The purpose of the study was to evaluate the long-term symptomatic and endoscopic outcome in gastroesophageal reflux disease with erosive esophagitis, comparing conservative with operative management. METHODS The study comprised 105 of 120 patients consecutively referred for severe reflux symptoms to the gastroenterologic outpatient department(More)
OBJECTIVES:There is no previous study concerning long term results of open Nissen fundoplication performed by general surgeons in a nonspecialized unit.METHODS:Of 45 consecutive patients in a general provincial center, 39 were available for follow-up after a mean period of 78 months. All patients were interviewed using a standard questionnaire, and 35 of(More)