Josip Saban

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The oim strain of mice is one of several rodent models that exhibit an osteogenesis imperfecta (OI) phenotype. These mice have a mutation in the gene encoding alpha-2 chain of type I procollagen that prevents proper assembly of this propeptide with alpha-1 propeptides. Homozygous oim mice experience multiple bone fractures under standard laboratory animal(More)
The regulation of bone deposition and remodeling is highly complex. To further understand the influence of growth hormone on bone deposition, several lines of transgenic mice were generated that expressed the human growth hormone gene (hGH) driven by beta-globin regulatory elements. In situ hybridization confirmed that the hGH gene in these mice was(More)
A protocol has been developed to distinguish between wild-type, heterozygous and homozygous oim mutant mice. Oim mice (The Jackson Laboratory, Bar Harbor, ME, USA) have a singlebase deletion in their proα2(I) collagen gene (cola-2 gene). This mutation changes the reading frame at the 3′ end of the mRNA causing synthesis of an altered C-propeptide that(More)
The sheep beta F globin gene has been sequenced completely, including 829 bases of 5' flanking region and 1368 bases 3' to the stop codon. In evolutionary terms, this gene is a homolog of the adult beta-like globin genes, including human beta. Over the course of evolution of Bovidae (comprised of sheep, goats, and cattle) the expression of beta F has become(More)
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