Josiane Valadão Lopes

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Increased levels of oxidative stress markers and/or decreased levels of antioxidant molecules have been described in patients with multiple sclerosis (MS). This imbalance has been implicated in demyelination and axonal damage. The aims of this study were to evaluate oxidative stress in MS patients and to verify its correlation with disability as assessed by(More)
BACKGROUND AND OBJECTIVE Women with multiple sclerosis (MS) who intend to get pregnant are often advised to discontinue disease modifying therapy (DMT) prior to conception. This recommendation is not based on medical evidence and may interfere with disease control by immunomodulatory drugs. The present study was designed to help discuss the effect of DMT(More)
OBJECTIVE To evaluate the frequency of anxiety and depression disorders in patients with chronic pain. METHOD Patients receiving care at the pain clinic of the Federal University of Bahia between February 2003 and November 2006. The MINI PLUS--Mini International Neuropsychiatric Interview was used to evaluate the patients and establish psychiatric(More)
OBJECTIVE To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). METHODS Data collection from neurologists attending to patients with MS at specialized units in Brazil. RESULTS Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the(More)
UNLABELLED Chronic pain causes functional incapacity and compromises an individual's affective, social, and economic life. OBJECTIVE To study the cognitive behavioral therapy (CBT) effectiveness in a group of patients with chronic pain. METHODS A randomized clinical trial with two parallel groups comprising 93 patients with chronic pain was carried out.(More)
There is evidence that activated immune-inflammatory and oxidative and nitrosative stress (IO&NS) pathways play a role in the pathophysiology of multiple sclerosis (MS) and depression. This study examines serum levels of interleukin (IL)-1β, IL-4, IL-6, and IL-10; peroxides (LOOH); nitric oxide metabolites (NOx); albumin; ferritin; C-reactive protein (CRP);(More)
OBJECTIVE To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. METHODS Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. RESULTS Analysis of(More)
OBJECTIVE It was to report on Brazilian cases of neurological complications from bariatric surgery. The literature on the subject is scarce. METHOD Cases attended by neurologists in eight different Brazilian cities were collected and described in the present study. RESULTS Twenty-six cases were collected in this study. Axonal polyneuropathy was the most(More)
Inflammation is the driving force for brain injury in patients with multiple sclerosis (MS). The objective of the present study is to delineate the serum cytokine profile in patients with progressive MS in a Southern Brazilian population compared with healthy controls and patients with relapsing-remitting MS (RRMS) and its associations with disease(More)
UNLABELLED The Neurological Fatigue Index for Multiple Sclerosis (NFI-MS) is a new fatigue assessment instrument. The aim of this study was to cross-culturally adapt and assess the psychometric properties of the Brazilian version of the NFI-MS (NFI-MS/BR). METHOD Two hundred and forty subjects with MS were recruited for this study. The adaptation of the(More)