Josiah A. Hoskins

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The first step in oral absorption of many medically important peptide-based drugs is mediated by an intestinal proton-dependent peptide transporter. This transporter facilitates the oral absorption of beta-lactam antibiotics and angiotensin-converting enzyme inhibitors from the intestine into enterocytes lining the luminal wall. A monoclonal antibody that(More)
The neurotoxic agent MPTP produces profound and sustained changes in the biochemistry of the brain in mice after a single dose of 20 mg/kg. Acute neurochemical changes have been examined in detail in 8 strains of mice. Coloured mice were more intoxicated than white mice when treated with MPTP: white mice were little affected behaviourally by a dose that(More)
The plant enzyme phenylalanine ammonia lyase (PAL) will survive in the gut for long enough to deplete the phenylalanine derived from food protein and so reduce the rise in blood phenylalanine that otherwise occurs after a protein meal. This effect has been demonstrated in healthy adults and phenylketonuric (PKU) patients. When the enzyme was given to an(More)
This paper presents a novel application of ray tracing techniques to the development of a model for simulating the dynamics of pure, even-aged boreal forest stands. In this study, the spatial distribution of the individual trees, together with the latitude, longitude, orientation of the test plot, and the degree of shade intolerance of the species were(More)
This paper describes the application of ray tracing, rendering, and morphing technology to the study and analysis of the spread of dwarf mistletoe. The practical problems involved in examining the spread and speed of such a slow pathogen, with such serious economic consequences, is illustrated. Tbe utility of applying this standard graphics technology to(More)
• miss paper discusses the development of a multimedia transfer technology system for the information contained in and required by the Canadian Forest Fire Behavior Prediction (FBP) System. The multimedia system consists of a diverse set of visual, numerical, and empirical models unified in their approach to simulating, explaining and elaborating the(More)
In vitro solubility testing is an important means of assessing the likely behavior of fibers that are respired and accumulate in the lung. The problem has been that such tests often do not mirror the dissolution and removal mechanisms seen in vivo. Comparison of iron and silica solubility values of various types of mineral fiber showed no obvious(More)
We have been examining a number of chemically modified mineral fibers, derived from amosite asbestos, by in vitro methods to clarify the role of the fiber surface in determining biological activity. The various fibers have identical size distributions but differ in their affinities for components of the cell membrane. They were treated with boiling toluene(More)
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